Molecular mechanisms of cell adehsion

The Gullberg laboratory has characterized the integrin α11β1, which is expressed on subsets of normal fibroblasts and on carcinoma-associated fibroblasts. Cells lacking α11β1 display disturbed cell-collagen interactions, altered metalloproteinase synthesis and reduced cell proliferation. Major projects within the group aim to further understand the role of this collagen receptor and other fibroblast integrins during health and in disease.

MEDOD1

MEDOD2

BMED320

BMED325

BMED330

FARM260

2025

• Anna De Giuseppe; Adrian Deichsel; Alina Reese et al. (2025). Collagen-binding integrin α11β1 contributes to joint destruction in arthritic hTNFtg mice. (external link)

1996

• Kristofer Rubin; Donald Gullberg; Bianca Tomasini-Johansson et al. (1996). Molecular Recognition of the Extracellular Matrix by Cell Surface Receptors. (external link)

2008

• Donald Gullberg (2008). How to keep that stemmy-ness: Stem cells in the spotlight. (external link)

2022

• Cedric Zeltz; Roya Navab; Ritva Leena Heljasvaara et al. (2022). Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?. (external link)

2015

• Jan-Niklas Schulz; Cedric Zeltz; Ida Wiig Sørensen et al. (2015). Reduced Granulation Tissue and Wound Strength in the Absence of α11β1 Integrin. (external link)

2017

• Pugazendhi Murugan Erusappan; Donald Gullberg (2017). Molecular aspects of integrin α11 function. (external link)
• Andreas Romaine; Ida Wiig Sørensen; Cedric Zeltz et al. (2017). Overexpression of integrin α11 induces cardiac fibrosis in mice. (external link)

2016

• Roya Navab; Dan Strumpf; Christine To et al. (2016). Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer. (external link)

See a complete overview of publications in NVA.

1990 Phd Medical Chemistry, Uppsala University

1990-1992 Post Doc, Molecular Biology Institute, University of California Los Angeles

1993-2003 Researcher, Uppsala University

2004- today Professor, Department of Biomedicine, UoB