My research aim is to characterize and better understand the major signaling pathways involved in endocrine disease, specifically diabetes development and adreno-gonadal development, by studying developing cells differentiated from induced pluripotent stem cells (iPSCs) generated from families with monogenic disease or other patients with adreno-gonadal conditions.

https://raederlab.w.uib.no/

http://www.uib.no/diabetes/80059/node-6-stamcelleforskning

https://raederlab.wordpress.com/

https://www.facebook.com/raederlab/

I teach pediatric topics to medical students, including lectures and bedside teaching. My lectures include Growth and Puberty Disorders (MED12) and Intoxication and Fluid Therapy (MED9) (Department of Clinical Science). 

I also teach metabolic diseases for Nutrition students (NUC352, Department of Clinical Medicine).

I also contribute to teaching in Master Courses (BMED330; Department of Biomedicine).

I also lead two Elective Courses at the Medical Faculty (Department of Clinical Science):

ELMED303 (Future Medicine)

ELMED223 (Innovation and Entrepeneurship)

I also organize and teach pediatric residents at the Course in Pediatric Endocrinology with topics including Calcium metabolism and case demonstrations.

2025

• Yue Wu; Ben Ehlert; Ahmed A. Metwally et al. (2025). Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology. (external link)
• Kristin Skjervold; Henriette Nordahl Sævig; Helge Ræder et al. (2025). DiaGuide-LLM—Using large language models for patient-specific education and health guidance in diabetes. (external link)
• Ingvild Müller Seljeseth; Henrik Sørlie; Sverre Kalfgraff et al. (2025). An Experience Sampling Study of Physiologically Measured Sleep and Objective Task Performance. (external link)

2026

• Ingvild Müller Seljeseth; Henrik Sørlie; Sverre Kalgraf et al. (2026). Nightly Sleep and Daily Task Performance: an Experience Sampling Study of Physiologically Measured Sleep and Objective Task Performance.. (external link)

2012

• Ingfrid S. Haldorsen; Helge Ræder; Mette Vesterhus et al. (2012). The role of pancreatic imaging in monogenic diabetes mellitus. (external link)
• Helge Ræder; Anders Molven; Pål Rasmus Njølstad (2012). Skreddersydd medisin eller narsissomikk?. (external link)
• E. Nazli Gonc; Burcu Bulum Ozturk; Ingfrid S. Haldorsen et al. (2012). HNF1B mutation in a Turkish child with renal and exocrine pancreas insufficiency, diabetes and liver disease. (external link)

2019

• Kenichiro Furuyama; Simona Chera; Leon van Gurp et al. (2019). Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. (external link)
• Heidrun Vethe; Luiza Ghila; Magnus Berle et al. (2019). The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. (external link)
• Thomas Aga Legøy; Luiza Ghila; Heidrun Vethe et al. (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. (external link)
• Heidrun Vethe; Thomas Aga Legøy; Shadab Abadpour et al. (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. (external link)
• Larry Sai Weng Loo; Heidrun Vethe; Andreas Alvin Purnomo Soetedjo et al. (2019). Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors. (external link)
• Natasha Hui Jin Ng; Joanita Binte Jasmen; Chang Siang Lim et al. (2019). HNF4A haploinsufficiency in MODY1 abrogates liver and pancreas differentiation from patient-derived induced pluripotent stem cells. (external link)
• Yngvild Bjørlykke; Anne Mette Søviknes; Laurence Hoareau et al. (2019). Reprogrammed cells display distinct proteomic signaturesAssociated with colony morphology variability. (external link)

2004

• Jørn V. Sagen; Helge Ræder; Eba Hathout et al. (2004). Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2 - Patient characteristics and initial response to sulfonylurea therapy. (external link)

2006

• Helge Raeder; Helge Ræder; Lise Bjorkhaug et al. (2006). A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry. (external link)
• Helge Ræder; Pål Rasmus Njølstad (2006). Ny type diabetes. (external link)
• Helge Ræder; Stefan Johansson; Pål I. Holm et al. (2006). Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. (external link)
• Helge Ræder (2006). Novel monogenic causes of diabetes and pancreatic exocrine dysfunction. (external link)

2008

• Helge Ræder; Nick Shaw; C. Netelenbos et al. (2008). A case of X-linked hypophosphatemic rickets: complications and the therapeutic use of cinacalcet. (external link)
• Helge Ræder; Robert Bjerknes (2008). X-bundet hypofosfatemisk rakitt: Ny kunnskap om patofysiologi, behandling og oppfølging. (external link)
• Anders Molven; Monika Ringdal; Anita-Merete Nordbø et al. (2008). Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. (external link)
• Jens Kristoffer Hertel; Stefan Johansson; H Ræder et al. (2008). Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). (external link)
• Mette Vesterhus; Ingfrid Salvesen Haldorsen; Helge Ræder et al. (2008). Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. (external link)
• Mette Vesterhus; Helge Ræder; Stefan Johansson et al. (2008). Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. (external link)
• Karianne Fjeld; Janniche Torsvik; Stefan Johansson et al. (2008). Structural changes in the repeated region of the carboxyl-ester lipase (CEL) gene and the development of diabetes. (external link)
• Ingfrid Salvesen Haldorsen; Mette Vesterhus; Helge Ræder et al. (2008). Lack of pancreatic body and tail in HNF1B mutation carriers. (external link)
• Stig Åge Eide; H Ræder; Helge Ræder et al. (2008). Prevalence of HNF1A (MODY3) mutations in a Norwegian population (the HUNT2 Study). (external link)
• Jørn V. Sagen; Lise Bjørkhaug; Janne Molnes et al. (2008). Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. (external link)
• Mette Vesterhus; Helge Ræder; Harald Aurlien et al. (2008). Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. (external link)

2013

• Adrian K.K. Teo; Rebecca Windmueller; Bente Berg Johansson et al. (2013). Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young. (external link)
• Erling Tjora; Gaute K Wathle; Friedemann Erchinger et al. (2013). Exocrine pancreatic function in hepatocyte nuclear factor 1 beta-maturity-onset diabetes of the young (HNF1B-MODY) is only moderately reduced: compensatory hypersecretion from a hypoplastic pancreas. (external link)
• Helge Ræder; Mette Vesterhus; Abdelfattah El Ouaamari et al. (2013). Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). (external link)
• Silje Hjorth Rafaelsen; Helge Ræder; Anne Kristine Fagerheim et al. (2013). Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification. (external link)
• Erling Tjora; Gaute K Wathle; Trond Engjom et al. (2013). Severe pancreatic dysfunction but compensated nutritional status in monogenic pancreatic disease caused by carboxyl-ester lipase mutations. (external link)
• Oddmund Søvik; Henrik Underthun Irgens; Janne Molnes et al. (2013). Monogenetic diabetes mellitus in Norway :. (external link)

2017

• Heidrun Vethe; Yngvild Bjørlykke; Luiza Ghila et al. (2017). Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. (external link)
• Kenneth Verheggen; Helge Ræder; Frode Berven et al. (2017). Anatomy and evolution of database search engines—a central component of mass spectrometry based proteomic workflows. (external link)

2023

• Hanne Scholz; Helge Ræder (2023). Response to Comment on Carrasco et al. Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. Diabetes 2022;71:862-869. (external link)
• Hassan Abdel-Raouf Abdel-Wahab Ali; Salwa Suliman; Tarig Al-Hadi Osman et al. (2023). Xeno-free generation of human induced pluripotent stem cells from donor-matched fibroblasts isolated from dermal and oral tissues. (external link)

2014

• Helge Ræder; Fiona E. McAllister; Erling Tjora et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. (external link)
• Yngvild Bjørlykke; Heidrun Vethe; Marc Vaudel et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young disease protein biomarkers in secretin-stimulated duodenal juice. (external link)
• Silje Hjorth Rafaelsen; Stefan Johansson; Helge Ræder et al. (2014). Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. (external link)

1996

• Helge Ræder; M. Aaberg; Per Omvik (1996). Unchanged 24-hour ambulatory blood pressure during short-term salt restriction and salt repletion in normotensive subjects. (external link)

2016

• Silje Hjorth Rafaelsen; Stefan Johansson; Helge Ræder et al. (2016). Hereditary hypophosphatemia in Norway: A retrospective population-based study of genotypes, phenotypes, and treatment complications. (external link)
• Luis Francisco Hernandez Sanchez; Elise Aasebø; Frode Selheim et al. (2016). Systemic Analysis of Regulated Functional Networks. (external link)
• Marc Vaudel; Harald Barsnes; Helge Ræder et al. (2016). Using Proteomics Bioinformatics Tools and Resources in Proteogenomic Studies. (external link)
• Marc Vaudel; Kenneth Verheggen; Attila Csordas et al. (2016). Exploring the potential of public proteomics data. (external link)
• Adrian Kee Keong Teo; Hwee Hui Lau; Ivan Achel Valdez et al. (2016). Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia. (external link)

2007

• Helge Ræder; Ingfrid Salvesen Haldorsen; Lars Ersland et al. (2007). Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-Ester lipase. (external link)
• Mette Vesterhus; Stefan Johansson; Helge Ræder et al. (2007). Pancreatic exocrine deficiency is common in MODY 3. (external link)
• Stefan Johansson; Helge Ræder; Stig Åge Eide et al. (2007). Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians. (external link)

2020

• Manoj K. Gupta; Heidrun Vethe; Samir Softic et al. (2020). Leptin receptor signaling regulates protein synthesis pathways and neuronal differentiation in pluripotent stem cells. (external link)
• Luiza Ghila; Yngvild Bjørlykke; Thomas Aga Legøy et al. (2020). Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. (external link)
• Thomas Aga Legøy; Heidrun Vethe; Shadab Abadpour et al. (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. (external link)

2011

• Gaya Thanabalasingham; Nabi Shah; Martine Vaxillaire et al. (2011). A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. (external link)
• Bente Berg Johansson; Janniche Torsvik; Lise Bjørkhaug et al. (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. (external link)
• Ingfrid S. Haldorsen; Helge Ræder; Mette Vesterhus et al. (2011). The role of pancreatic imaging in monogenic diabetes. (external link)
• Jens Kristoffer Hertel; Stefan Johansson; Helge Ræder et al. (2011). Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study). (external link)

2024

• Chencheng Wang; Shadab Abadpour; Aleksandra Aizenshtadt et al. (2024). Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling. (external link)
• Chencheng Wang; Shadab Abadpour; Petter Angell Olsen et al. (2024). Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells. (external link)
• Ingvild Müller Seljeseth; Henrik Sørlie; Janne Grønli et al. (2024). Nightly Sleep and Daily Job Task Performance: An Experience Sampling Study. (external link)

2015

• Øyvind Helgeland; Jens Kristoffer Hertel; Anders Molven et al. (2015). The chromosome 9p21 CVD- and T2D-associated regions in a Norwegian population (the HUNT2 survey). (external link)

2002

• Helge Ræder; Maria Ræder; Pål Rasmus Njølstad (2002). Klinisk molekylærmedisin:DNA-sekvensering. (external link)

2022

• Manuel Carrasco Fernandez; Chencheng Wang; Anne Mette Søviknes et al. (2022). Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. (external link)
• Marie Søfteland Sandvei; Geir Wenberg Jacobsen; Marianne Heldal Stien et al. (2022). A national intercalated medical student research program –student perceptions, satisfaction, and factors associated with pursuing a PhD. (external link)
• Thomas Aga Legøy; Andreas Frøslev Mathisen; Hanne Scholz et al. (2022). Molecular mechanisms affecting islet like cell fate acquisition in differentiating iPSC derived β-like cells”. (external link)
• Mette Pernille Myklebust; Anne Mette Søviknes; Ole Johan Halvorsen et al. (2022). MicroRNAs in Differentiation of Embryoid Bodies and the Teratoma Subtype of Testicular Cancer. (external link)
• Camilla Tvedt Ekanger; Fan Zhou; Dana Bohan et al. (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. (external link)
• Sevim Kahraman; Ercument Dirice; Giorgio Basile et al. (2022). Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8. (external link)

2021

• Luiza Ghila; Thomas Aga Legøy; Andreas Frøslev Mathisen et al. (2021). Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human ipsc-derived pancreatic progenitors. (external link)
• Laurence Hoareau; Agnete Engelsen; Marianne Aanerud et al. (2021). Induction of alveolar and bronchiolar phenotypes in human lung organoids. (external link)
• Chencheng Wang; Shadab Abadpour; Alexandra Aizenshtadt et al. (2021). Glucose during in vitro pancreatic beta cells regeneration: friends or for?. (external link)
• Chencheng Wang; Shadab Abadpour; Alexandra Aizenshtadt et al. (2021). 402.2: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells. (external link)
• Man Hung Choi; Erling Tjora; Rakel Brendsdal Forthun et al. (2021). KRAS mutation analysis by droplet digital PCR of duodenal juice from patients with MODY8 and other pancreatic diseases. (external link)

2010

• Pål Rasmus Njølstad; Jens Kristoffer Hertel; Oddmund Søvik et al. (2010). Fremskritt innen diabetesgenetikk. (external link)
• Janniche Torsvik; Stefan Johansson; Anders Johansen et al. (2010). Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes. (external link)
• Hana Lango Allen; Stefan Johansson; Sian Ellard et al. (2010). Polygenic risk variants for Type 2 Diabetes susceptibility modify age at diagnosis in Monogenic HNF1A Diabetes. (external link)
• Mette Vesterhus; Helge Ræder; Amarnath J Kurpad et al. (2010). Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. (external link)

2005

• Lise Bj. Gundersen; Stefan Johansson; Helge Ræder et al. (2005). Molekylærgenetisk diagnostikk ved diabetes mellitus. (external link)

2018

• Geir Wenberg Jacobsen; Helge Ræder; Marianne Heldal Stien et al. (2018). Springboard to an academic career - A national medical student research program. (external link)
• Bente Berg Johansson; Karianne Fjeld; Khadija el Jellas et al. (2018). The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. (external link)

See a complete overview of publications in NVA.

https://scholar.google.com/citations?user=ecPm_OoAAAAJ&hl=en