The main research aim is to characterize metabolic phenotypes of human leukemia cells, and investigate how metabolic pathways may be implicated in the development of cancer cells`drug resistance.
Additional research interests include the contribution of the microenvironment in acute myeloid leukemia (AML); in particular how leukemia cells are influenced by stromal cells and chemokines, and how leukemia cells adapt to changes in oxygen levels and nutrient availability.

2026

• Silje Johansen; Guido Smits; Kristin Paulsen Rye et al. (2026). Endothelial mediators and association with chronic graft-versus-host disease in allogeneic hematopoietic stem cell transplantation: a retrospective single-center study. (external link)
• Marte Karen Brattås; Kimberley Joanne Hatfield; Kristin Paulsen Rye et al. (2026). Metabolomics profiling of acute myelogenous leukemia patients to identify systemic differences associated with in vitro sensitivity to SYK inhibitors. (external link)

2012

• Håkon Reikvam; Kimberley Joanne Hatfield; Hanne Kristin Fredly et al. (2012). The angioregulatory cytokine network in human acute myeloid leukemia - from leukemogenesis via remission induction to stem cell transplantation. (external link)
• Øystein Bruserud; Håkon Reikvam; Astrid Marta Olsnes Kittang et al. (2012). High-dose etoposide in allogeneic stem cell transplantation. (external link)

2009

• Håkon Reikvam; Kimberley Joanne Hatfield; Anne Margrete Øyan et al. (2009). Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors; release profile and pharmacological modulaion. (external link)

2010

• Kimberley Joanne Hatfield; Siv Lise Bedringaas; Anita Ryningen et al. (2010). Hypoxia increases HIF-1 alpha expression and constitutive cytokine release by primary human acute myeloid leukaemia cells. (external link)

2022

• Kimberley Joanne Hatfield; Øystein Bruserud; Håkon Reikvam (2022). Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients. (external link)

2015

• Håkon Reikvam; Annette Brenner; Karen Marie Hagen et al. (2015). The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells. (external link)

2016

• Michelle Victoria Hauge; Øystein Bruserud; Kimberley Joanne Hatfield (2016). Targeting of cell metabolism in human acute myeloid leukemia - more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling?. (external link)

2025

• Marte Karen Brattås; Franziska Stilla Maria Görtler; Silje Johansen et al. (2025). Gene Expression Profiling in Acute Myeloid Leukemia Patient Subgroups With High and Low Sensitivity Toward SYK Inhibitors. (external link)

See a complete overview of publications in NVA.

Bergen Research Foundation funded project: Characterization of metabolic phenotypes and signaling pathways in acute myeloid leukemia and their role in anti-leukemia treatment.