- giil.melver@uib.no
- Visitor address
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Haukeland universitetssykehus, Laboratoriebygget
5009 Bergen - Postal address
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P.O. Box 7804NO-5020 BergenNorway
Research groups
Short info
Studies on biomarkers in blood and cerebrospinal fluid in primary (neurodegenrative) and secondary (delirium) brain diseases, with a focus on biochemical and immunological processes. Minor works on statistics, immunology and heart disease.
Outreach
See about the kynurenine pathway https://www.jci.org/posts/680 and listen about glucose metabolism https://academic.oup.com/brain/pages/podcast (podcast 14. februar 2024) in delirium.
Teaching
History taking and clinical examination for medical students.
Publications
Academic article
- Monika Trzpis; Giil Lasse Melvær; Johannes Espolin Roksund Hov et al. (2026). Assessment of the bacteria-derived metabolite TMAO as a potential factor contributing to the pathophysiology of delirium in elderly patients with hip fracture. (external link)
- Hanne Edøy Heszlein-Lossius; Yahya Al-Borno; Samar Shaqqoura et al. (2019). Traumatic amputations caused by drone attacks in the local population in Gaza: a retrospective cross-sectional study. (external link)
- Desirée Rodrigues Plaça; Dennyson Leandro M. Fonseca; Alexandre H. C. Marques et al. (2024). Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection. (external link)
- Alberto Jaramillo-Jiménez; Giil Lasse Melvær; Diego Alejandro Tovar-Rios et al. (2021). Association Between Amygdala Volume and Trajectories of Neuropsychiatric Symptoms in Alzheimer’s Disease and Dementia With Lewy Bodies. (external link)
- Stein-Erik Hafstad Solvang; Allison Hodge; Leiv Watne et al. (2022). Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging. (external link)
- Adrian McCann; Giil Lasse Melvær; Arve Ulvik et al. (2019). Plasma amino acids and incident type 2 diabetes in patients with coronary artery disease. (external link)
- Giil Lasse Melvær; Dag Aarsland (2020). Greater Variability in Cognitive Decline in Lewy Body Dementia Compared to Alzheimer's Disease. (external link)
- Miguel Germán Borda; Dag Aarsland; Diego Alejandro Tovar-Rios et al. (2020). Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy body dementia. (external link)
- Arne Olav Ervik; Stein-Erik Hafstad Solvang; Jan Erik Nordrehaug et al. (2019). The associations between cognitive prognosis and kynurenines are modified by the apolipoprotein ε4 allele variant in patients with dementia. (external link)
- Giil Lasse Melvær; Silja Hanseth; Ognjen Bojovic et al. (2023). The inverse association between the apolipoprotein E ε4 allele and C-reactive protein levels is stronger in persons with obesity and diabetes. (external link)
- Irit Titlestad; Leiv Watne; Gideon A. Caplan et al. (2023). Impaired glucose utilization in the brain of patients with delirium following hip fracture. (external link)
- Miguel Germán Borda; Alberto Jaramillo-Jiménez; Giil Lasse Melvær et al. (2022). Body mass index trajectories and associations with cognitive decline in people with Lewy body dementia and Alzheimer's disease. (external link)
- Guri Fossdal; Anders Batman Mjelle; Kristine Wiencke et al. (2021). Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF. (external link)
- Anne-Brita Knapskog; Trine Holt Edwin; Per Magne Ueland et al. (2024). Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease. (external link)
- Adrian McCann; Dag Aarsland; Per Magne Ueland et al. (2021). Serum tyrosine is associated with better cognition in Lewy body dementia. (external link)
- Anders Lund; Giil Lasse Melvær; Grete Slettom et al. (2018). Antibodies to receptors are associated with biomarkers of inflammation and myocardial damage in heart failure. (external link)
- Magnus Leidland; Britt Undheim; Anagha P. Parker et al. (2021). Lungeembolisme hos en pasient med Klinefelters syndrom. (external link)
- Paula P. Freire; Alexandre Marques; Gabriela C. Baiocchi et al. (2021). The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age. (external link)
- Ingrid Kvestad; Adrian McCann; Ram K. Chandyo et al. (2021). One-Carbon Metabolism in Nepalese Infant-Mother Pairs and Child Cognition at 5 Years Old. (external link)
- Audun Osland Vik-Mo; Giil Lasse Melvær; Clive Ballard et al. (2018). Course of neuropsychiatric symptoms in dementia: 5-year longitudinal study. (external link)
- Otavio Cabral-Marques; Alexandre Marques; Giil Lasse Melvær et al. (2018). GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis. (external link)
- Leiv Otto Watne; Christian Thomas Pollmann; Bjørn Erik Neerland et al. (2022). Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients. (external link)
- Lysandro P. Borges; Adriana G. Guimarães; Dennyson Leandro M. Fonseca et al. (2022). Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities. (external link)
- Einar Vie Sundal; Giil Lasse Melvær (2020). Alvorlig delir etter GHB-misbruk. (external link)
- Anne Brita Knapskog; Mari Aksnes; Trine Holt Edwin et al. (2023). Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease. (external link)
- Hanne Edøy Heszlein-Lossius; Yahya Al-Borno; Samar Shaqqoura et al. (2018). Life after conflict-related amputation trauma: A clinical study from the Gaza Strip. (external link)
- Gabriela C. Baiocchi; Aristo Vojdani; Avi Z. Rosenberg et al. (2023). Cross-sectional analysis reveals autoantibody signatures associated with COVID-19 severity. (external link)
- Anagha P Parkar; Miraude E.A.M.P. Adriaensen; Giil Lasse Melvær et al. (2019). Computed Tomography Assessment of Anatomic Graft Placement After ACL Reconstruction: A Comparative Study of Grid and Angle Measurements. (external link)
- Caroline Aliane de Souza Prado; Dennyson Leandro M. Fonseca; Youvika Singh et al. (2023). Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID-19 severity. (external link)
- Giil Lasse Melvær; Dag Aarsland; Kristoffer Herland Hellton et al. (2018). Antibodies to multiple receptors are associated with neuropsychiatric symptoms and mortality in Alzheimer's disease: A longitudinal study. (external link)
- Anders Lund; Jan Erik Nordrehaug; Grete Slettom et al. (2020). Plasma kynurenines and prognosis in patients with heart failure. (external link)
- Audun Osland Vik-Mo; Lasse Melvær Giil; Miguel Germán Borda et al. (2019). The individual course of neuropsychiatric symptoms in people with Alzheimer’s and Lewy body dementia: 12-year longitudinal cohort study. (external link)
- Audun Skjærseth Hildre; Stein-Erik Hafstad Solvang; Dag Aarsland et al. (2020). Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia. (external link)
- Paul Denver; Lucas Tortorelli; Karen Roksund Hov et al. (2024). Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium. (external link)
- Miguel Germán Borda; Ana Maria Ayala Copete; Diego Alejandro Tovar-Rios et al. (2021). Association of malnutrition with functional and cognitive trajectories in people living with dementia: a five-year follow-up study. (external link)
- Stein-Erik Hafstad Solvang; Jan Erik Nordrehaug; Grethe S. Tell et al. (2019). The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study. (external link)
- Stein-Erik Hafstad Solvang; Jan Erik Nordrehaug; Dag Aarsland et al. (2019). Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia. (external link)
- Kristoffer Herland Hellton; Jeffrey Cummings; Audun Osland Vik-Mo et al. (2020). The Truth behind the Zeros: A New Approach to Principal Component Analysis of the Neuropsychiatric Inventory. (external link)
- Mari Kalland Knapstad; Ole Martin Steihaug; Mona Kristin Aaslund et al. (2019). Reduced Walking Speed in Subjective and Mild Cognitive Impairment: A Cross-Sectional Study. (external link)
- Irit Titlestad; Kristoffer Haugarvoll; Stein-Erik Hafstad Solvang et al. (2024). Delirium is frequently underdiagnosed among older hospitalised patients despite available information in hospital medical records. (external link)
- Lasse Melvær Giil (2022). Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity. (external link)
- Hanne Heszlein-Lossius; Yahya Al-Borno; Samar Shaqqoura et al. (2019). Does pain, psychological distress and deteriorated family economy follow traumatic amputation among war casualties? A retrospective, cross-sectional study from Gaza. (external link)
- Alberto Jaramillo-Jiménez; Giil Lasse Melvær; Miguel Germán Borda et al. (2023). Serum TCA cycle metabolites in Lewy bodies dementia and Alzheimer's disease: Network analysis and cognitive prognosis. (external link)
- Lasse Melvær Giil (2018). GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis. (external link)
- Anne Katrine Bergland; Hogne Sønnesyn; Ingvild Dalen et al. (2019). Effects of anthocyanin supplementation on serum lipids, glucose, markers of inflammation and cognition in adults with increased risk of dementia - A pilot study. (external link)
- Lasse Melvær Giil; Einar Klæboe Kristoffersen; Christian A. Vedeler et al. (2015). Autoantibodies toward the angiotensin 2 type 1 receptor: a novel autoantibody in Alzheimer's Disease. (external link)
- Otavio Cabral-Marques; Gilad Halpert; Lena F. Schimke et al. (2022). Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity. (external link)
- Giil Lasse Melvær; Øivind Midttun; Helga Refsum et al. (2017). Kynurenine pathway metabolites in Alzheimer's disease. (external link)
- Giil Lasse Melvær; Christian A. Vedeler; Einar Klæboe Kristoffersen et al. (2017). Antibodies to signaling molecules and receptors in Alzheimer's disease are associated with psychomotor slowing, depression, and poor visuospatial function. (external link)
- Giil Lasse Melvær; Dag Aarsland; Audun Osland Vik-Mo (2021). Differentiating traits and states identifies the importance of chronic neuropsychiatric symptoms for cognitive prognosis in mild dementia. (external link)
- Per Mølstad; Jan Erik Nordrehaug; Terje Steigen et al. (2020). The effect of drug-eluting stents on target lesion revascularization in native coronary arteries: Results from the NORSTENT randomized study. (external link)
- Petra Vogelsang; Giil Lasse Melvær; Anders Lund et al. (2018). Reduced glucose transporter-1 in brain derived circulating endothelial cells in mild Alzheimer's disease patients. (external link)
- Giil Lasse Melvær; Stein-Erik Hafstad Solvang; Malin Melvaer Giil et al. (2019). Serum Potassium Is Associated with Cognitive Decline in Patients with Lewy Body Dementia. (external link)
Letter to the editor
Journal corrigendum
- Lysandro P. Borges; Adriana G. Guimarães; Dennyson Leandro M. Fonseca et al. (2023). Corrigendum to “Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities” [Heliyon 8 (11) (November 2022) Article e11368] (Heliyon (2022) 8(11), (S2405844022026561), (10.1016/j.heliyon.2022.e11368)). (external link)
- Anne Katrine Bergland; Hogne Sønnesyn; Ingvild Dalen et al. (2021). Corrigendum: Effects of Anthocyanin Supplementation on Serum Lipids, Glucose, Markers of Inflammation and Cognition in Adults With Increased Risk of Dementia – A Pilot Study (Front. Genet., (2019), 10, (536), 10.3389/fgene.2019.00536). (external link)
Academic literature review
Doctoral thesis (PhD)
Awards
Our paper on Quinolinic acid in delirium was awarded as a publication of excellence during the year from the University of Oslo: https://www.oslo-universitetssykehus.no/om-oss/nyheter/priser-til-fremragende-forskningsartikler-publisert-hosten-2022. (external link)