Mette Vesterhus
Position
Full Professor, Head of Teaching
Affiliation
- mette.vesterhus@uib.no
- Visitor address
-
Haukeland universitetssykehus, Laboratoriebygget
5009 Bergen - Postal address
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P.O. Box 7804NO-5020 BergenNorway
Mette Vesterhus
Position
Full Professor, Head of Teaching
Affiliation
Research groups
Research
Mette Vesterhus, M.D. (UiB 1999), Ph.D. (UiB 2009), works as Full Professor at the University of Bergen and Senior Consulting Gastroenterologist & Hepatologist at Haraldsplass Deaconess Hospital in Bergen, Norway. With a particular focus on primary sclerosing cholangitis (PSC) and other autoimmune liver diseases, her main areas of interest are prognostic biomarkers and non-invasive assessment of liver fibrosis (including liver elastography), as well as clinical trials in autoimmune liver diseases. She is Group Leader of the Haraldsplass Liver Research Group and Clinical Group Bergen of the Norwegian PSC Research Center (NoPSC) and National PI for the Strategic Prospective Scandinavian PSC Biobank (ScandPSC). Internationally, she is a Board Member of the International PSC Study Group as well as the UEG Meeting of Members.
Publications
Academic article
- Peder Rustøen Braadland; Ahmad H. Ali; Philip Puchas et al. (2026). Vitamin B6 predicts poor outcomes in geographically distinct populations with primary sclerosing cholangitis. (external link)
- Bregje Mol; Moyrha van Nieuwamerongen; Kim N. van Munster et al. (2025). Proctocolectomy with permanent ileostomy is associated with improved transplant-free survival in patients with PSC. (external link)
- Yashbir Singh; John E. Eaton; Sudhakar K. Venkatesh et al. (2025). Deep learning analysis of MRI accurately detects early-stage perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis. (external link)
- Peder Rustøen Braadland; Annika Bergquist; Martin Kummen et al. (2023). Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. (external link)
- Silje Fjellgård Jørgensen; Marius Trøseid; Martin Kummen et al. (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. (external link)
- Annika Bergquist; Tobias J. Weismüller; Cynthia Levy et al. (2022). Impact on follow-up strategies in patients with primary sclerosing cholangitis. (external link)
- Amandeep Kaur Dhillon; Christian Rupp; Annika Bergquist et al. (2021). Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis. (external link)
- Peder Rustøen Braadland; Kai Markus Schneider; Annika Bergquist et al. (2022). Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis. (external link)
- Yashbir Singh; William A. Jons; John E. Eaton et al. (2022). Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis. (external link)
- Francesca Saffioti; Davide Roccarina; Mette Vesterhus et al. (2019). Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis. (external link)
- Martin Kummen; Mette Vesterhus; Marius Trøseid et al. (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. (external link)
- Helge Ræder; Fiona E. McAllister; Erling Tjora et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. (external link)
- Anesa Mulabecirovic; Anders Batman Mjelle; Mette Vesterhus et al. (2016). In Vitro Comparison of Five Different Elastography Systems for Clinical Applications, Using Strain and Shear Wave Technology. (external link)
- Felix Bende; Anesa Mulabecirovic; Alina Popescu et al. (2017). Assessing liver stiffness by 2-D shear wave elastography in a healthy cohort. (external link)
- Anesa Mulabecirovic; Anders Batman Mjelle; Odd Helge Gilja et al. (2017). Repeatability of shear wave elastography in liver fibrosis phantoms—Evaluation of five different systems. (external link)
- Anders Batman Mjelle; Anesa Mulabecirovic; Roald Flesland Havre et al. (2020). Liver elastography in healthy children using three different systems - how many measurements are necessary?. (external link)
- Amandeep Kaur Dhillon; Andreas E. Kremer; Martin Kummen et al. (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. (external link)
- Mette Vesterhus; Ingfrid Salvesen Haldorsen; Helge Ræder et al. (2008). Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. (external link)
- Roman Zenouzi; T Liwinski; J Yamamura et al. (2018). Follow-up magnetic resonance imaging/3D-magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret. (external link)
- Ainhoa Lapitz; Mikel Azkargorta; Piotr Milkiewicz et al. (2023). Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma. (external link)
- Martin Kummen; Louise B. Thingholm; Malte C. Rühlemann et al. (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. (external link)
- Helge Ræder; Mette Vesterhus; Abdelfattah El Ouaamari et al. (2013). Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). (external link)
- Omar Y Mousa; Brian D Juran; Bryan M. McCauley et al. (2020). Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation. (external link)
- Mette Vesterhus; Mette Juul Nielsen; Johannes Roksund Hov et al. (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. (external link)
- Guri Fossdal; Anders Batman Mjelle; Kristine Wiencke et al. (2021). Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF. (external link)
- Lars Bossen; Mette Nåmdal Vesterhus; Johannes Espolin Roksund Hov et al. (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. (external link)
- Jeffrey V. Lazarus; Henry E. Mark; Alina M. Allen et al. (2023). A global action agenda for turning the tide on fatty liver disease. (external link)
- Victoria Resvik Taraldsen; Sunneva Tomasgard; Margrethe Thune Rudlang et al. (2020). Point shear wave elastography and the effect of physical exercise, alcohol consumption, and respiration in healthy adults. (external link)
- Holmfridur Helgadottir; Geir Folvik; Mette Nåmdal Vesterhus (2022). Improvement of cholestatic episodes in patients with benign recurrent intrahepatic cholestasis (BRIC) treated with rifampicin. A long-term follow-up. (external link)
- JE Eaton; Mette Vesterhus; Bryan M. McCauley et al. (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. (external link)
- Anders Batman Mjelle; Anesa Mulabecirovic; Edda Jonina Olafsdottir et al. (2021). Controlled Attenuation Parameter in Healthy Individuals Aged 8-70 Years. (external link)
- Anders Batman Mjelle; Anesa Mulabecirovic; Trygve Hausken et al. (2016). Ultrasound and point shear wave elastography in livers of patients with primary sclerosing cholangitis. (external link)
- Mette Vesterhus; Helge Ræder; Stefan Johansson et al. (2008). Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. (external link)
- Eike Matthias Wacker; Florian Uellendahl-Werth; Saptarshi Bej et al. (2023). Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis. (external link)
- Charlotte Rose Hawkey Hedin; Gina Sado; Nelson Ndegwa et al. (2020). Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis. (external link)
- PJ Trivedi; J Tickle; Mette Vesterhus et al. (2017). Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner. (external link)
- Anesa Mulabecirovic; Mette Vesterhus; Odd Helge Gilja et al. (2016). In vitro comparison of five different elastography systems for clinical applications, using strain and shear wave technology. (external link)
- Bente Berg Johansson; Janniche Torsvik; Lise Bjørkhaug et al. (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. (external link)
- Elisabeth M.G. de Vries; Martti Färkkilä; Piotr Milkiewicz et al. (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. (external link)
- Mette Vesterhus; Johannes Espolin Roksund Hov; Anders Holm et al. (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. (external link)
- Anesa Mulabecirovic; Anders Batman Mjelle; Odd Helge Gilja et al. (2018). Liver elasticity in healthy individuals by two novel shear-wave elastography systems-Comparison by age, gender, BMI and number of measurements. (external link)
- Ingfrid S. Haldorsen; Helge Ræder; Mette Vesterhus et al. (2011). The role of pancreatic imaging in monogenic diabetes. (external link)
- MJ Nielsen; Douglas Thorburn; DJ Leeming et al. (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. (external link)
- Martin Kummen; Kristian Holm; Jarl Andreas Anmarkrud et al. (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. (external link)
- Anders Batman Mjelle; Guri Fossdal; Odd Helge Gilja et al. (2020). Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems. (external link)
- Guri Fossdal; Peder Rustøen Braadland; Johannes Espolin Roksund Hov et al. (2025). Mitochondrial dysfunction and lipid alterations in primary sclerosing cholangitis. (external link)
- Anders Batman Mjelle; Anesa Mulabecirovic; Roald Flesland Havre et al. (2019). Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods. (external link)
- Kevin De Muynck; Lander Heyerick; Federico F. De Ponti et al. (2023). Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis. (external link)
- Ingfrid Salvesen Haldorsen; Mette Vesterhus; Helge Ræder et al. (2008). Lack of pancreatic body and tail in HNF1B mutation carriers. (external link)
- Tom Hemming Karlsen; Mette Vesterhus; Kirsten Muri Boberg (2014). Review article: Controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. (external link)
- Tea Lund Laursen; Lars Bossen; Rasmus Pihl et al. (2022). Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases. (external link)
- EC Goode; AB Clark; GM Melis et al. (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. (external link)
- Mette Vesterhus; Espen Melum (2016). Prognostic biomarkers and surrogate end points in PSC.. (external link)
- Amandeep Kaur Dhillon; Martin Kummen; Marius Trøseid et al. (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. (external link)
- Mette Vesterhus; Anders Holm; Johannes Espolin Roksund Hov et al. (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. (external link)
- Mette Vesterhus; Helge Ræder; Harald Aurlien et al. (2008). Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. (external link)
- Mette Vesterhus; Helge Ræder; Amarnath J Kurpad et al. (2010). Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. (external link)
- Serge J. Zweers; Alexey Shiryaev; Mina Komuta et al. (2016). Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. (external link)
- Johannes Espolin Roksund Hov; Kirsten Muri Boberg; Eli Taraldsrud et al. (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. (external link)
- Sebastian Torben Jendrek; Daniel Gotthardt; Thomas Nitzsche et al. (2017). Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. (external link)
Conference poster
- Joachim Høg Mortensen; Aida Kapic Lunder; Tina Manon-Jensen et al. (2020). P117 Biomarkers of extracellular matrix remodelling are associated with intestinal fibrosis assessed by magnetic resonance enterography and accumulated intestinal damage (Lémann index): the IBSEN study. (external link)
- Anders Batman Mjelde; Trygve Hausken; Tom Hemming Karlsen et al. (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis.. (external link)
- Martin Kummen; Mette Vesterhus; Marius Trøseid et al. (2015). P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis.. (external link)
- Anesa Mulabecirovic; Mette Vesterhus; Odd Helge Gilja et al. (2015). In vitro quantification and reproducibility of elasticity measurements using four different ultrasound scanners. (external link)
- Anesa Mulabecirovic; Felix Bende; I Sporea et al. (2017). ASSESSING LIVER STIFFNESS USING 2D-SHEAR WAVE ELASTOGRAPHY IN A HEALTHY COHORT. (external link)
- Martin Kummen; Mette Vesterhus; Marius Trøseid et al. (2015). MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS. (external link)
Academic literature review
- Ingfrid S. Haldorsen; Helge Ræder; Mette Vesterhus et al. (2012). The role of pancreatic imaging in monogenic diabetes mellitus. (external link)
- Jeffrey V. Lazarus; Henry E. Mark; Quentin M. Anstee et al. (2021). Advancing the global public health agenda for NAFLD: a consensus statement. (external link)
- Tom Hemming Karlsen; Trine Folseraas; Douglas Thorburn et al. (2017). Primary sclerosing cholangitis - a comprehensive review. (external link)
- Ansgar W. Lohse; Marcial Sebode; Marianne H. Jørgensen et al. (2020). Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. (external link)
- Mette Nåmdal Vesterhus; Kristine Wiencke; John Willy Haukeland et al. (2021). Klinisk oversiktsartikkel: Diagnostikk og behandling av autoimmun hepatitt. (external link)
- Mette Vesterhus; Tom Hemming Karlsen (2020). Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. (external link)
- Holmfridur Helgadottir; Mette Nåmdal Vesterhus (2023). Noninvasive evaluation of fibrosis in adult biliary diseases. (external link)
Professional article
- Nasir Hussain; Christopher Ma; Gideon Hirschfield et al. (2024). Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis. (external link)
- Holmfridur Helgadottir; Trine Folseraas; Gunter Kemmerich et al. (2023). Primær skleroserende kolangitt. (external link)
- Eivind Ness-Jensen; Birgitte Karen Berggreen Seip; Mette Vesterhus (2020). Prioriteringsråd for fordøyelsessykdommer under korona-pandemien. (external link)
Media feature article
Editorial/Leader article
Letter to the editor
- Ansgar W. Lohse; Marcial Sebode; Mette Nåmdal Vesterhus (2021). Reply to: "Both tacrolimus and mycophenylate mophetil should be considered second-line therapy for autoimmune hepatitis". (external link)
- John Willy Haukeland; Mette Nåmdal Vesterhus; Kristin Kaasen Jørgensen et al. (2023). FIB-4-testen som beslutningsverktøy. (external link)
Lecture
- Mette Nåmdal Vesterhus (2021). ELF Test in PSC - should we start using it?. (external link)
- Mette Nåmdal Vesterhus (2021). 2.linjebehandling ved PBC og AIH. (external link)
- Mette Nåmdal Vesterhus (2021). Juvenile PSC/ASC: The adult side.. (external link)
- Mette Nåmdal Vesterhus (2021). ULTRASOUND EVALUATION OF PSC. (external link)
- Mette Nåmdal Vesterhus (2021). PSC - What is that disease exactly?. (external link)
- Anesa Mulabecirovic; Mette Vesterhus; Odd Helge Gilja et al. (2017). Ultralyd Elastografi. (external link)
- Anesa Mulabecirovic; Anders Batman Mjelle; Odd Helge Gilja et al. (2017). Måling av vevsstivhet på fantomer med fire ulike «shear wave» elastografisystemer. (external link)
Doctoral thesis (PhD)
Academic book chapter
Conference abstract
Conference lecture
- Martin Kummen; Kristian Holm; Jarl Andreas Anmarkrud et al. (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE. (external link)
- Anesa Mulabecirovic; Mette Vesterhus; Odd Helge Gilja et al. (2015). In vitro quantification and reproducibility of elasticity measurements using five different elastography systems. (external link)
- Anesa Mulabecirovic; Anders Batman Mjelle; Roald Flesland Havre et al. (2016). Quantification of tissue elasticity in vitro using three clinical shear wave elastography platforms on liver fibrosis phantoms. (external link)
- Anders Batman Mjelle; Anesa Mulabecirovic; Trygve Hausken et al. (2016). Elastography of the Liver in Primary Sclerosing Cholangitis. (external link)