Publications using MIC

Below are annual lists of publications (last ten years) that reflect the use of MIC’s services. It is important that users acknowledge MIC in their publications and notify us once a paper has been accepted.

2026

TBA

2025 -until July
  1. Berle BF, Juliussen S, Castilho A, Solel E, Saed HS, Vanderpoorten O, Lunavat TR, Thorsen F, Rigg E. Multimodal imaging of brain metastasis-derived extracellular vesicles using superparamagnetic iron oxide nanoparticle labeling. Int J Nanomedicine 2025 Jun 13:20:7501-7514. doi: 10.2147/IJN.S520791.
  2. Ekanger CT, Ramnefjell MP, Guttormsen MSF, Hekland J, Dahl-Michelsen K, Lotsberg ML, Lu N, Stuhr LEB, Hoareau L, Salminen PR, Gärtner F, Aanerud M, Akslen LA, Lorens JB, Engelsen AST. An organoid model for translational cancer research recapitulates histoarchitecture and molecular hallmarks of non-small-cell lung cancer. Cancers (Basel) 2025 Jun3;17(11):1873. doi: 10.3390/cancers17111873.
  3. Espedal H, Lyngstad JM, Berg HF, Hjelmeland ME, Fasmer KE, Krakstad C, Haldorsen IS. Evaluation of early chemotherapy response by combining static- and dynammic [18F]FDG-PET with diffusion-weighted MRI in subcutaneous patent-derived endometrial cancer mouse models. EJNMMI Res 2025 Apr 18;15(1):45. doi: 10.1186/s13550-025-01235-5.
  4. Gravdal A, Wilhelm SJ, CEL-MODY Mouse Project, Lowe ME, Molven A, Xiao XK, Fjeld K. The MODY-causing mutation of the human carboxyl ester lipase gene (CEL) triggers chronic pancreatitis but not diabetes in mice. Gastroenterology 2025 Jul;169(1):161-164.e6. doi:10.1053/j.gastro.2025.01.243.
  5. Gundersen ET, Wang Z, Førde JL, Larquet E, Æsøy R, Roussel H, Tosi L, Barratt G, Herfindal L, Legrand FX. Repurposing chlorpromazine for anti-leukaemic therapy with the drug-in-cyclodextrin-in-liposome nanocaarrier platform. Carbohydr Polym 2025 Jun 15:358:123478. doi: 10.1016/j.carbpol.2025.123478.
  6. Kaminska M, Kalucka U, Babickova J, Benedyk-Machaczka M, Skandalou E, Grant MM, Marti HP. Bradykinin´s carbamylation as a mechanistic link to impaired would healing in patients with kidney dysfunction. BMC Biol 2025 Mar 12;23(1):76. doi: 10.1186/s12915-025-02187-x.
  7. Mellgren AEC, Cristea I, Stevenson T, Spriet E, Knappskog PM, Bøe SO, Kranz H, Grellscheid SN, Rødahl E. On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469. FEBS Open Bio. 2025 Jul;15(7):1054-1067. doi: 10.1002/2211-5463.70034. Epub 2025 Mar 29.PMID: 40156465 
  8. Solel E, Brudvik E, Ystaas LAR, Yabo YA, Rigg E, Choudhury RR, Saed HS, Heiland DH, Bjerkvig R, Hossain J, Miletic H. Gasdermin E in glioblastoma-pyroptosis resistance and tumor-promoting functions. Cell Death Disc 2025 Jun 21;11(1):284. doi: 10.1038/s41420-025-02572-z.
  9. Velasco K, Torsvik J, St-Louis JL, Baghestani S, Silvander JSG, Kulkarni RN, Toivola DM, Molven A. Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic b-cells. BMC Mol Cell Biol 2025 Jun 5;26(1):18. doi: 10.1186/s12860-025-00544-w.
  10. Wikerholmen T, Taule EM, Rigg E, Berle BF, Sættem M, Sarnow K, Saed HS, Sundstrøm T, Thorsen F. Repurposing neuroleptics: clozapine as a novel, adjuvant therapy for melanoma brain metastaes. Clin Exp Metastasis, 2025 Jan 25;42(2):12. doi: 10.1007/s10585-025-10328-3.

 

2024
  1. Augis L, Reiten IN, Førde JL, Casas-Solvas JM, Sizun C, Bizien T, Rajkovic I, Larquet E, Michelet A, Collot M, Lesieur S Herfindal L, Legrand FX. Development of nanoparticles based on amphiphilic cyclodextrins for the delivery of active substances. Int J Pharm 2024 Feb 15, 651:123723. doi: 10.1016/j.ijpharm.2023.123723.
  2. Baldinotti R, Pauzin FP, Fevang H, Ishizuka Y, Bramham CR. A nanobody-based proximity ligation assay detects constitutive and stimulus-regulated native Arc/Arg3.1 oligomers in hippocampal neuronal dendrites. Mol Neurobiol Oct 5, 2024. doi: 10.1007/s12035-024-04508-7.
  3. Bjørnstad OV, Carrasco M, Finne K, Ardawatia V, Winge I, Askeland C, Arnes JB, Knutsvik G, Kleftogiannis D, Paulo JA, Akslen LA, Vethe H. Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model. EBioMedicine Oct, 2024. 108:105325. doi: 10.1016/j.ebiom.105325.
  4. Casey NP, Kleinmanns K, Forcados C, Gelebart PF, Joaquina S, Lode M, Benard E, Kaveh F, Caulier B, Helgestad Gjerde C, Garcia de Jálon E, Warren Dj, Lindemann K, Rokkones E, Davidson B, Myhre MR, Kvalheim G, Bjørge L, McCormack E, Inderberg EM, Wälchli S. Efficient CAR T targeting of the CA125 extracellular repeat domain of MUC16. J Immunother Cancer 2024 Apr 11, 12(4):e008179. doi: 10.1136/jitc-2023-008179.
  5. Caulier B, Joaquina S, Gelebart P, Dowling TH, Kaveh F, Thomas M, Tandaric L, Wernhoff P, Katyayini NU, Wogsland C, Gjerstad ME, Fløisand Y, Kvalheim G, Marr C, Kobold S, Enserink JM, Gjertsen BT, McCormack E, Inderberg EM, Wälchli S. CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia. Cell Rep Med 2024 Jun 18, 5(6):101572. doi: 10.1016/j.xcrm.2024.101572.
  6. Chelban V, Aksnes H, Maroofian R, LaMonica LC, Seabra L, Siggervåg A, Devic P, Shamseldin HE, Vandrovcova J, Murphy D, Richard AC, Quenez O, Bonnevalle A, Zanetti MN, Kaiyrzhanov R, Salpietro V, Efthymiou S, Schottlaender LV, Morsy H, Scardamaglia A, Tariq A, Pagnamenta AT, Pennavaria A, Krogstad LS, Bekkelund ÅK, Caiella A, Glomnes N, Brønstad KM, Tury S, Moreno DeLuca A, Boland-Auge A, Olaso R, Deleuze JF, Anheim M, Cretin B, Vona B, Alajlan F, Abdulwahab F, Battini JL, Ipek R, Bauer P, Zifarelli G, Gungor S, Kurul SH, Lochmuller H, Daás SI, Fakhro KA, Gómez-Pascual A, Botía JA, Wood NW, Horvath R, Ernst AM, Rothman JE, McEntagart M, Crow YJ, Alkuraya FS, Nicolas G, SYNaPS Study Group, Arnesen T, Houlden H. Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications. Nat Comm 2024 Mar 13, 15(1):2269. Doi: 10.1038/s41467-024-46354-0.
  7. Espedal H, Fasmer KE, Berg HF, Lyngstad JM, Schilling T, Krakstad C, Haldorsen IS. MRI radiomics captures early treatment response in patient-derived organoid endometrial cancer mouse models. Front Oncol 2024 May 7, 14:1334541. doi: 10.3389/fonc.2024.1335641.
  8. Grøndal SM, Blø M, Nilsson LIH, Rayford AJ, Jackson A, Gausdal G, Lorens JB. Targeting AXL cellular networks in kidney fibrosis. Front Immunol Nov 2024; 4:15:1446672. doi: 10.3389/fimmu.2024.1446672.
  9. Høyland LE, VanLinden MR, Niere M, Strømland Ø, Sharma S, Dietze J, Tolås I, Lucena E, Biulco E, Sverkeli LJ, Cimadamore-Werthein C, Ashrafi H, Haukanes KF, van der Hoeven B, Dölle C, Davidsen C, Pettersen IKN, Tronstad KJ, Mjøs SA, Hayat F, Makarov MV, Migaud ME, Heiland I, Ziegler M. Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+. Nat Metab Dec 2024; 6(12):2319-2337. doi: 10.1038/s42255-024-01174-w.
  10. Johansen Å, Lin J, Yamada S, Mohamed-Ahmed S, Yassin MA, Gjerde C, Hutchinson DJ, Mustafa K, Malkoch M. Photo-clickable triazine-trione thermosets as promising 3D scaffolds for tissue engineering applications. Adv Healthc Mater 2024 Jul, 17:e2401202. doi: 10.1002/adhm.202401202.
  11. Kanli G, Boudissa S, Jirik R, Adamsen T, Espedal H, Rolfsnes HO, Thorsen F, Pacheco-Torres J, Janji B, Keunen O. Quantitative pre-clinical imaging of hypoxia and vascularity using MRI and PET. Methods Cell Biol Nov 19, 2024. doi: 10.1016/bs.mcb.2024.10.016.
  12. Krokengen OC, Touma C, Mularsski A, Sutinen A, Dunkel R, Ytterdal M, Raasakka A, Mertens HD, Simonsen AC, Kursula P. The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes. Biochim Biophys Acta Biomembr 2024 Jul4, 1866(7):184368. doi: 10.1016/j.bbamem.2024.184368.
  13. Liang KX, Chen A, Kianian A, Kristiansen CK, Yangzom T, Furriol J, Høyland LE, Ziegler M, Kråkenes T, Tzoulis C, Fang EF, Sullivan GJ, Bindoff LA. Activation of neurotoxic astrocytes due to mitochondrial dysfunction triggered by POLG mutation. Int J Biol Sci 2024 May 11, 20(8):2860-2880. doi: 10.7150(ijbs.93445.
  14. Madan E, Palma A, Accardi D, Beliao S, Camacho D, Peixoto M, Beltran A, Moreno E, Vudatha V, Trevino J, Wilhelm J, Dreier I, Yekelchyk M, Araujo T, Garre E, Gustafsson A, Landberg G, Neufeld L, Yeini T, Sachi-Fainaro R, Rolfsnes H, Bjerkvig R, Thorsen F, Kim H, Martin P, Won KJ, Kumar A, Bhoopati P, Fisher P, Liao L, Gupta K, Chaudhary S, Nagane M, Dorayappan K, Karuppaiyah S, Natarajan K, Kuppusamy P, Correia I, da Silva C, Fialho A, Wang H, Wicha M, Sidransky D, Grossman S, Drapkin R, Connolly D, Godwin A, Winn R, Ackermann M, Tzankov A, Pelham C, Gogna R. Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironmental cells. Nature Biotechnol  Dec 9, 2024. doi: 10.1038/s41587-024-02453-3.
  15. Mathisen AF, Larsen U, Kavli N, Unger L, Daian LM, Vacaru AM, Vacaru AM, Herrera PL, Ghila L, Chera S. Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption. Commun Biol 2024 Jul 9, 7(1):833. doi: 10.1038/s42003-024-06527-5.
  16. Mathisen AF, Legøy TA, Larsen U, Unger L, Abadpour S, Paulo JA, Scholz H, Ghila L, Chera S. The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop. Mech Ageing Dev 2024 Aug:220:111951. doi: 10.1016/j.2024.111951.
  17. Mathisen AF, Vacaru AM, Unger L, Lamba EM, Mardare QAM, Daian LM, Ghila L, Vacaru AM, Chera S. Molecular profiling of NOD mouse islets reveals a novel regulator of insulitis onset. Sci Rep 2024 Jun 25, 14(1):14669. doi: 10.1038/s41598-024-65454-x.
  18. Musiime M, Erusappan PM, Cukierman E, Chang J, Molven A, Hansen U, Zeltz C, Gullberg D. Fbroblast integrin a11b1 is a collagen assembly receptor in mechanoregulated fibrillar adhesions. Matrix Biol 2024 Dec:134:144-161. doi: 10.1016/j.matbio.2024.10.006.
  19. Roesler J, Spitzer D, Jia X, Aasen SN, Sommer K, Roller B, Olshausen N, Hebach NR, Albinger N, Ullrich E, Zhu L, Wang F, Macas J, Forster MT, Steinbach JP, Sevenich L, Devraj K, Thorsen F, Karreman MA, Plate KH, Reiss Y, Harter PN. Disturbance in cerebral blood circulation and hypoxic-ischemic microenvironment are associated with the development of brain metastasis. Neuro Oncol Jun 4, 2024. doi: 10.1093/neuonc/noae094.
  20. Rostad KO, Trognitz T, Frøyset AK, Bifulco E, Fladmark KE. Accelerated sarcopenia phenotype in the DJ-1/Park7-knockout zebrafish. Antioxidants (Basel) 2024 Dec 11;13(12):1509. doi: 10.3390/antiox13121509.
  21. Safont MM, Leitch C, Popa M, Gjerstad ME, Caulier B, Inderberg EM, Wälchli S, Gelebart P, McCormack E. Protocol for the development of a bioluminescent AML-PDX mouse model for the evaluation of CAR T cell therapy. STAR Protoc 2024 Dec 20;5(4):103522. doi: 10.1016/j.xpro.2024.103522.
  22. Shanbhag S, Al-Sharabi N, Kampleitner C, Mohamed-Ahmed S, Kristoffersen EK, Tangl S, Mustafa K, Gruber R, Sanz M. The use of mesenchymal stromal cell secretome to enhance guided bone regeneration in comparison with leukocyte and platelet-rich fibrin. Clin Oral Implants Res 2024 Feb, 35(2):141-154. oi: 10.1111/clr.14205.
  23. Unger L, Mathisen AF, Chera S, Legøy TA, Ghila L. The GLI code controls HNF1A levels during foregut differentiation. Int J Dev Biol 2024 Jan 17. doi: 10.1387/ijdb.230220Ig.
  24. Yamada S, Al-Sharabi N, Torelli F, Volponi AA, Sandven L, Ueda M, Fristad I, Mustafa K. Harnessing the antioxidative potential of dental pulp stem cell-conditioned medium in photopolymerized GelMA hydrogels. Biomater Res 2024 Sep 17:28:0084. doi: 10.34133/bmr.0084.
2023
  1. Bartaula-Brevik S, Leitch C, Hernandez-Valladares M, Aasebø E, Berven FS, Selheim F, Brenner AK, Rye KP, Hagen M, Reikvam H, McCormack E, Bruserud Ø, Tvedt THA. Vacuolar ATPase is a possible therapeutic target in acute myeloid leukemia: Focus on patient heterogeneity and treatment toxicity. J Clin Med 2023 Aug 25, 12(17):5546. doi: 10.3390/jcm12175546.
  2. Bjørnstad OV, Carrasco M, Finne K, Winge I, Askeland C, Arnes JB, Knutsvik G, Kleftogiannis D, Paulo JA, Akslen LA, Vethe H. Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model. bioRxiv 2023 May 5. doi: 10.1101/2023.05.03.539050.
  3. Cristea I, Abarca H, Mellgren AEC, Trubnykova M, Mehrasa R, Peters DJM, Houge G, Hennekam RCM, Rødahl E, Bruland O, Bredrup C. A Pellino-2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium-digital keloid dysplasia. FEBS Lett 2023 May;597(9):1290-1299. doi: 10.1002/1873-3468.14597.
  4. Gelebart P, Gjerstad ME, Benjaminsen S, Han J, Karlsen I, Safont MM, Leitch C, Fandalyuk Z, Popa M, Helgeland L, Papp B, Baran-Marszak F, McCormack E. Inhibition of a new AXL isoform, AXL3, induces apoptosis of mantle cell lymphoma cells. Blood 2023 Oct 26, 142(17):1478-1493. doi: 10.1182/blood.2022015581.
  5. Hong Y, Kristiansen CK, Chen A, Nido GS, Høyland LE, Ziegler M, Sullivan GJ, Bindoff LA, Liang KX. POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia. Exp Neurol 2023 Jul;365:1144429. doi: 10.1016/j.expneurol.2023.114429.
  6. Law JO, Jones CM, Stevenson T, Williamson TA, Turner MS, Kusumaatmaja H, Grellscheid SN. A bending rigidity parameter for stress granule condensates. Sci Adv 2023 Mar 29;24(7):6456. doi:10.3390/ijms24076456.
  7. Mehrasa R, Cristea I, Bredrup C, Rødahl E, Bruland O. Functional characterization of all-trans retinoic acid-induced differentiation factor (ATRAID). FEBS Open Bio 2023 Oct, 13(10):1874-1886. doi: 10.1002/2211-5463.13685.
  8. Miftari M, Walther BT. Leukolectin-proteins are synthesized and secreted by leucocytes, a distinct category of fish embryonic mucus cells. Fish Shellfish Immunol 2023 Jun;137:108730. doi:10.1016/j.fsi.2023.108730.
  9. Oftedal BE, Berger AH, Bruserud Ø, Goldfarb Y, Sulen A, Breivik L, Hellessen A, Ben-Dor S, Haffner-Krausz R, Knappskog PM, Johansson S, Wolff AS, Bratland E, Abramson J, Husebye ES. A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrom type 1. J Clin Invest 2023 Nov 1, 133(21):e169704. doi: 10.1172/JCI169704.
  10. Rigg E, Wang J, Xue Z, Lunavat TR, Liu G, Hoang T, Parajuli H, Han M, Bjerkvig R, Nazarov PV, Nicot N, Kreis S, Margue C, Nomigni MT, Utikal J, Miletic H, Sundtstrøm T, Ystaas LAR, Li X, Thorsen F. Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathwaydysregulation in astrocytes. J Extracell Vesicles 2023 12:12363. doi: 10.1002/jev2.12363.
  11. Shanbhag S, Kampleitner C, Al-Sharabi N, Mohamed-Ahmed S, Alccayhuaman KAA, Heimel P, Tangl S, Beinlich A, Rana N, Sanz M, Kristoffersen EK, Mustafa K, Gruber R. Functionalizing collagen membranes with MSC-conditioned media promotes guided bone regeneration in rat calvarial defects. Cells 2023 Feb 28;12(5):767. doi:10.3390/cells12050767.
  12. Spitzer D, Khel MI, Pütz T,  Zinke J, Jia X, Sommer K, Filipksi K, Thorsen F, Freiman TM, Günther S, Plate KH, Harter PN, Liegner S, Reiss Y, Di Tacchio M, Guèrit S, Devraj K. A flow cytometry-based protocol for syngenic isolation of neurovascular unit cells from mouse and human tissues. Nat Protocol 18:1510-1542, 2023. doi: 10.1038/s41596-023-00805-y.
  13. Szapoczka WK, Truskewycz AL, Skodvin T, Holst B, Thomas PJ. Fluorescence intensity and fluorescence lifetime meadurements of various carbon dots as a function of pH. Sci Rep 2023 Jun30, 1281):10660. Doi: 10.1038/s41598-023-37578-z.
  14. Tidwell TR, Røsland G, Tronstad KJ, Søreide K, Hagland HR. Comparing in vitro cytotoxic drug sensitivity in colon and pancreatic cancer using 2D and 3D models: Contrasting viability and growth inhibition in clinically relevant dose and repeated drug cycles. Cancer Medicine 2024 May 8, 13:e7318. doi: 10.1002/cam4.7318.
  15. Uggerud IM, Kråkenes T, Hirai H, Vedeler CA, Schubert M. Development and optimization of a multilayer rat Purkinje neuron culture. Cerebellum 2023 Jan 10. doi:10.1007/s12311-022-01510-4.
  16. Varland S, Silva RD, Kjosås I, Faustino A, Bogaert A, Billmann M, Boukhatmi H, Kellen B, Costanzo M, Drazic A, Osberg C, Chan K, Zhang X, Tong AHY, Andreazza S, Lee JJ, Nedyalkova L, Moffat J, Myers CL, Gevaert K, Boone C, Martinho RG, Arnesen T. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Nat Commun 2023 Oct 27, 14(1):6774. doi: 10.1038/s41467-023-42342-y.
  17. Watson DC, Bayik D, Storevik S, Moreino SS, Sprowls SA, Han J, Augutssson MT, Lauko A, Sravya P, Røsland GV, Troike K, Tronstad KJ, Wang S, Sarnow K, Kay K, Lunavat TR, Silver DJ, Dayal S, Joseph JV, Mulkearns-Hubert E, Ystaas LAR, Deshpande G, Guyon J, Zhou Y, Magaut CR, Seder J, Neises L, Williford SE, Meiser J, Scott AJ, Sajjakulnukit P, Mears JA, Bjerkvig R, Chakraborty A, Daubon T, Cheng F, Lyssiotis CA, Wahl DR, Hjelmeland AB, Hossain JA, Miletic H, Lathia JD. GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. Nat Cancer 2023 May;4(5):648-664. doi:10.1038/s43018-023-00556-5.
  18. Yamada S, Yassin MA, Torelli F, Hansmann J, Green JBA, Schwarz T, Mustafa K. Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho-ROCK-mediated contractility dependent. Bioeng Transl Med 2023 Mar 17;8(3):e10509. doi:10.1002/btm2.10509.
2022
  1. Brattekås B, Sandnes MF, Steinsbø M, Cobos JE. A systematic investigation of polymer influence on core scale wettability aided by positron emission tomography imaging. Polymers (Basel) 2022 Nov 21;14(22):5050. doi:10.3390/polym14225050.
  2. Carrasco M, Wang C, Søviknes AM, Bjørlykke Y, Abadpour S, Paulo JA, Tjora E, Njølstad P, Ghabayen J, Nermoen I, Lyssenko V, Chera S, Ghila LM, Vaudel M, Sholz H, Ræder H. Spatial environment affects HNF4A mutation-specific proteome signatures and cellular morphology in hiPSC-derived b-like cells. Diabetes 2022 Apr 1;71(4):862-869, doi: 10.2337/db20-1279.
  3. Chaikitkaew S, In-chan S, Singkhala A, Tukanghan W, Mamimin C, Reungsang A, Birkeland NK, O-Thong S. Clostridium thailandense sp. nov., a novel CO2-reducing acetogenic bacterium isolated from peatland soil. Int J Syst Evol Microbiol 2022 Feb;72(2), doi: 10.1099/ijsem.0.005254.
  4. Chen A, Kristiansen CK, Høyland LE, Ziegler M, Wang J, Sullivan GJ, Li X, Bindoff LA, Liang KX. POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition. Cell Cycle 2022 Jun;21:21(11):1178-1193, doi: 10.1080/15384101.2022.2044136. 
  5. Ekanger CT, Zhou F, Bohan D, Lotsberg ML, Ramnefjell M, Hoareau L, Røsland GV, Lu N, Aanerud M, Gärtner F, Salminen PR, Bentsen M, Halvorsen T, Ræder H, Akslen LA, Langeland N, Cox R, Maury W, Stuhr LEB, Lorens JB, Engelsen AST. Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. Front Cell Infect Microbiol 2022 Mar 14;12:841447, doi: 10.3389/fcimb.2022.841447.
  6. Elsaid HOA , Furriol J , Blomqvist M , Diswall M , Leh S , Gharbi N, Anonsen JH , Babickova J, Tøndel C, Svarstad E, Marti HP , Krause M. Reduced α-galactosidase A activity in zebrafish ( Danio rerio) mirrors distinct features of Fabry nephropathy phenotype. Mol Genet Metab Rep. 2022 Feb 17:31:100851.doi: 10.1016/j.ymgmr.2022.100851. eCollection 2022 Jun.  
  7. Fjeld K, Gravdal A, Brekke RS, Alam J, Wilhelm SJ, El Jellas K, Pettersen HN, Lin J, Verbeke CS, Xiao X, Lowe ME, Molven A. The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice. Pancreatology 2022 Dec;22(8):1099-1111. doi:10.1016/j.pan.2022.11.003.
  8. Førde JL, Reiten IN, Fladmark KE, Kittang AO, Herfindal L. A new software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae. Biol Open 2022 Dec 15;11(12):bio059530. doi:10.1242/bio.059530.
  9. Gundersen ET, Førde JL, Tislevoll BS, Leitch C, Barratt G, Gjertsen BT, Herfindal T. Repurposing chlorpromazine for anti-leukemic therapy by nanoparticle encapsulation. Int J Pharm 2022 Jan 25;612:121296, doi: 10.1016/j.ijpharm.2021.121296.
  10. Hara K, Hellem, Yamada S, Sariibrahimoglu, Mølster A, Gjerdet NR, Hellem S, Mustafa K, Yassin MA. Efficacy of treating segmental bone defects through endochondral ossification: 3D printed designs and bone metabolic activities. Mater Today Bio 2022 Mar 7;14:100237, doi: 10.1016/j.mtbio.2022.100237. 
  11. Javier-Lopez R, Mandolini E, Dzhuraeva M, Bobodzhanova K, Birkeland NK. Fervidobacterium pennivorans subsp. Keratinolyticus subsp. Nov., a novel feather-degrading anaerobic thermopile. Microorganisms 2022 Dec 21;11(1):22. doi: 10.3390/microorganisms11010022.
  12. Joseph JV, Magaut CR, Storevik S, Geraldo LH, Mathivet T, Latif MA, Rudewicz J, Guyon J, Gambaretti M, Haukas F, Trones A, Ystaas LAR, Hossain JA, Ninzima S, Cuvellier S, Zhou W, Tomar T, Klink B, Rane L, Irving BK, Marrison J, O´Toole P, Wurdak H, Wang J, Di Z, Birkeland E, Berven FS, Winkler F, Kruyt FAE, Bikfalvi A, Bjerkvig R, Daubon T, Miletic H. TGF-b promotes microtube formation in glioblastoma through thrombospondin 1. Neuro Oncol 2022 Apr 1;24(4):541-553, doi: 10.1093/neuonc/noab212.
  13. Kleinmanns K, Gullaksen SE, Bredholt G, Davidson B, Torkildsen CF, Grindheim S, Bjørge L, McCormack E. Humanized ovarian cancer patient-derived xenografts for improved preclinical evaluation of immunotherapies. Cancers (Basel) 2022 Jun 23;14(13):3092. doi: 10.3390/cancerscancers14133092.
  14. Kristiansen CK, Chen A, Høyland LE, Ziegler M, Sullivan GJ, Bindoff LA, Liang KX. Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations. Cell Cycle 2022 Jul 10;1-16. doi: 10.1080/15384101.2022.2092185.
  15. Liu JH, Peter DO, Guttormsen SMF, Hossain MK, Gerking Y, Veruki ML, Hartveit E.  The mosaic of All amacrine bodies in rat retina is indistinguishable from a random distribution. Vis Neurosci 2022 May 10;39:E004, doi: 10.1017/S0952523822000025.
  16. Lotsberg ML, Røsland GV, Rayford AJ, Dyrstad SE, Ekanger CT, Lu N, Frantz K, Stuhr LEB, Ditzel HJ, Thiery JP, Akslen LA, Lorens JB, Engelsen AST. Intrinsic differences in spatiotemporal organization and stromal cell interactions between isogenic lung cancer cells of epithelial and mesenchymal phenotypes revealed by high-dimensional single-cell analysis of heterotypic 3D spheroid models. Front Oncol 2022 Apr 22;12:818437. doi: 10.3389/fonc.2022.818437. 
  17. Markússon S, Hallin EI, Bustad HJ, Raasakka A, Xu J, Muruganandam G, Loris R, Martinez A, Bramham CR, Kursula P. High-affinity anti-Arc nanobodies provide tools for structural and functional studies. PLoS One 2022 Jun 7;17(6):e0269281, doi: 10.1371/journal.pone.0269281.
  18. Popa M, Fosse V, Kleinmanns K, McCormack E. Xenograft models of ovarian cancer for therapy evaluation. Methods Mol Biol 2022;2424;275-293. doi: 10.1007/978—1-0716-1956-8_18.
  19. Rahman MA, Engelsen AST, Sarowar S, Bindesbøll C, Birkeland E, Goplen D, Lotsberg ML, Knappskog S, Simonsen A, Chekenya M. Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway. Front Cell Dev Biol 2022 Dec 22;10:102219. doi:10.3389/fcell.2022.1022191.
  20. Reigstad A, Herdlevær CF, Rigg E, Hoang T, Bjørnstad OV, Aasen SN, Preis J, Haan C, Sundstrøm T, Thorsen F. CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells. PLoS One 2022 Sep 9;17(9):e0273711. doi:10.1371/journal.pone.0273711.
  21. Saraste J, Enyioko M, Dale H, Prydz K, Machamer C. Evidence for the role of Rab11-positive recycling endosomes as intermediates in coronavirus egress from epithelial cells. Histochem Cell Biol 2022 Sep;158(3):241-251.doi:10.1007/s00418-022-02115-y.
  22. Yilmaz O, Jensen AM, Harboe T, Møgster M, Jensen RM, Mjaavatten O, Birkeland E, Spriet E, Sandven L, Furmanek T, Berven FS, Wargelius A, Norberg B. Quantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early development. BMC Genomics. 2022 Sep 7;23(1):635. doi: 10.1186/s12864-022-08859-0.PMID: 36071374 
  23. Zalieckas J, Mondragon IR, Pobedinskas P, Kristoffersen AS, Mohamed-Ahmed S, Gjerde C, Høl PJ, Hallan G, Furnes ON, Cimpan MR, Haenen K, Holst B, Greve MM. Polycrystalline diamond coating on orthopedic implants: realization and role of surface topology and chemistry in adsorption of proteins and cell proliferation. ACS Appl Mater Interfaces 2022 Oct 5;14(39):44933-44946. doi: 10.1021/acsami.2c10121.
2021
  1. Alhourani A, Tidwell TR, Bokil AA, Røsland GV, Tronstad KJ, Søreide K, Hagland HR. Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells. Sci Rep 2021 May 18, 11(1):10487. doi:10.1038/s41598-021-89861-6.
  2. Aubi O, Prestegård KS, Jung-Kc K, Shi TJS, Ying M, Grindheim AK, Scherer T, Ulvik A, McCann A, Spriet E, Thöny B, Martinez A. The Pah-R261Q mouse reveals oxidative stress associated with aymolid-like hepatic aggregation of mutant phenylalanine hydroxylase. Nat Commun 2021 Apr 6, 12(1):2073. doi:10.1038/s41467-021-22107-1.
  3. Berg HF, Hjelmeland ME, Lien H, Espedal H, Fonnes T, Srivastava A, Stokowy T, Strand E, Bozikovic O, Stefansson IM, Bjørge L, Trovik J, Haldorsen IS, Hoivik EA, Krakstad C. Patient-derived organoids reflect the genetic profile of endometrial tumors and predict patient prognosis. Commun Med (Lond) 2021 Jul 30;1:20. doi: 10.1038/s43856-021-00019-x.
  4. Bezem MT, Johannessen FG, Kråkenes TA, Sailor MJ, Martinez A. Relevance of electrostatics for the interaction of tyrosine hydroxylase with porous silicon nanoparticles. Mol Pharm 2021 Mar 1, 18(3):976-985. doi:10.1021/acs.molpharmaceut.0c00960.
  5. Chen A, Kristiansen CK, Yu H, Kianan A, Fang EF, Sullivan GJ, Wang J, Li X, Bindoff LA, Liang KX. Nicotinamide riboside and metformin ameliorate mitophagy defect in induced pluripotent stem cell-derived astrocytes with POLG mutations. Front Cell Dev Biol 2021 Sep 24;9:737304, doi: 10.3389/fcell.2021.737304. 
  6. Cristea I, Bruland O, Aukrust I, Rødahl E, Bredrun C. Pellino-2 in immune cells: novel interaction partners and intracellular localization. FEBS Lett 2021 Dec;595(23):2909-2921, doi: 10.1002/1873-3468.14212.
  7. Cristea I, Bruland O, Rødahl E, Bredrup C. K+ regulates relocation of Pellino-2 to the site of NLRP3 inflammasome activation in macrophages. FEBS Lett 2021 Oct;595(19):2437-2446, doi: 10.1002/1873-3468.14176. 
  8. de Garibay GR, de Jalón EG, Stigen E, Lund KB, Popa M, Davidson B, Safont MM, Rygh CB, Espedal H, Barrett TM, Haug BE, McCormack E. Repurposing 18F-FMISO as a PET tracer fpr translational imaging of nitroreductase-based gene directed enzyme prodrug delivary. Theranostics 2021 Apr 7, 11(12):6044-6057. doi:10.7150/thno.55092.
  9. De Jalón EG, Kleinmanns K, Fosse V, Davidson B, Bjørge L, Haug BE, McCormack E. Comparison of five near-infrared fluorescent folate conjugates in an ovarian cancer model. Mol Imaging Biol 2021 Dec 10. doi: 10.1007/s11307.021-01685-y.
  10. Dyrstad SE, Lotsberg ML, Tan TZ, Pettersen IKN, Hjellbrekke S, Tusubira D, Engelsen AST, Daubon T, Mourier A, Thiery JP, Dahl O, Lorens JB, Tronstad KJ, Røsland GV. Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect of non-small cell lung cancer. Cancers (Basel) 2021 Feb 24, 13(5)941. doi:10.3390/cancers13050941.
  11. Espedal H, Berg HF, Fonnes T, Fasmer KE, Krakstad C, Haldorsen IS. Feasibility and utility of MRI and dynamic 18F-FDG-PET in an orthotopic organoid-based patient-derived moude model of endometrial cancer. J Transl Med 2021 Sep 26;19(1):406. doi: 10.1186/s12967-021-03086-9.
  12. Gavgani FM, Slinning MS, Morovicz AP, Arnesen VS, Turcu DC, Ninzima S, D`Santos C, Lewis AE. Nuclear phosphatidylinositol 3,4,5-triphosphate interactome uncovers an enrichment in nucleolar proteins. Mol Cell Proteomics 2021;20:100102. doi: 10.1016/j.mcpro.2021.100102.
  13. Gharbi N, Røise D, Førre JE, Edson AJ, Hushagen HA, Tronci V, Frøyset AK, Fladmark KE. Reintoduction of DJ-1 in Müller cells inhibits retinal degeneration in the DJ-1 deficient retina. Antioxydants (Basel) 2021 Nov 23;10(12):1862, doi: 10.3390/antiox10121862.
  14. Ghila L, Legøy TA, Mathisen AF, Abadpour S, Paulo JA, Scholz H, Ræder H, Chera S. Chronically elevated exogenous glucose ilicits antipodal effects on the proteome signature of differentiating human iPSC-derived pancreatic progenitors. Int J Mol Sci 2021 Apr 2, 22(7):3698. doi:10.3990/ijms22073698.
  15. Gravdal A, Xiao X, Cnop M, Jellas KE, Johansson S, Njølstad PR, Lowe ME, Johansson BB, Molven A, Fjeld K. The position of single-based deletions in the VTNR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity. J Biol Chem 2021 Apr 13:100661. doi:10.1016/j.jbc.2021.100661.
  16. Helgeland E, Rashad A, Campodoni E, Goksoyr O, Pedersen TØ, Sandri M, Rosén A, Mustafa K. Dual-crosslinked 3D printed gelatin scaffolds with potential for temporomandibular joint cartilage regeneration. Biomed Mater 2021 Feb 16. doi:10.1088/1748-605X/abe6d9.
  17. Jain S, Yassin MA, Fuoco T, Mohamed-Ahmed S, Vindenes H, Mustafa K, Finne-Wistrand A. Understanding of how the properties of medical grade lactide based copolymer scaffolds influence adipose tissue regeneration: Sterilization and a systematic in vitro assessment. Mater Sci Eng C Mater Biol Appl 2021, May, 124: 112020.
  18. Liang KX, Vatne GH, Kristiansen CK, Ievglevskyi O, Kondratskaya E, Glover JC, Chen A, Sullivan GJ, Bindoff LA. N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation. Exp Neurol 2021 Mar, 337:113536. doi:10.1016/j.expneurol.2020.113536.
  19. Liu JH, Singh JB, Veruki LM, Hartveit E. Morphological properties of the axon initial segment-lie process of All amacrine cells in the rat retina. J Comp Neurol 2021 Nov;529(16):3593-3620, doi: 10.1002/cne.25210.
  20. Mannsåker TA, Hoang T, Aasen SN, Bjørnstad OV, Parajuli H, Sundstrøm T, Thorsen F. Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways. Int J Mol Sci 2021 Nov 14;22:12296, doi: 10.3390/ijms222212296.
  21. Mashzhan A, Javiér-Lopez R, Kistaubayeva A, Savitskaya I, Birkeland NK. Metagenomics and culture-based diversity analysis of the bacterial community in the Zharkent geothermal spring in Kazakhstan. Curr Microbiol 2021 May 28. doi:10.1007/s00284-021-02545-2.
  22. Mohamed-Ahmed S, Yassin MA, Rashad A, Espedal H, Idris SB, Finne-Wistrand A, Mustafa K, Vindenes H, Fristad I. Comparison of regenerative capacity of donor-matched human adipose-derived and bone marrow mesenchymal stem cells. Cell Tissue Res 2021 Mar, 383(3):1061-1075.
  23. Mostafavi S, Balafkan N, Pettersen IKN, Nido GS, Siller R, Tzoulis C, Sullivan GJ, Bindoff LA. Distinct mitochondrial remodeling during mesoderm differentiation in a human-based stem cell model. Front Cell Dev Biol 2021 Oct 14;9:744777,  doi: 10.3389/fcell.2021.744777.
  24. Pakdaman Y, Denker E, Austad E, Norton WHJ, Rolfsnes HO, Bindoff LA, Tzoulis C, Aukrust I, Knappskog PM, Johansson S, Ellingsen S. Chip protein U-Box domain truncation affects purkinje neuron morphology and leads to behavioral changes in zebrafish. Front Mol Neurosci 2021 Sep 24;14:723912, doi: 10.3389/fnmol.2021.723912. 
  25. Sachkova MY, Nordmann EL, Soto-Ángel JJ, Meeda Y, Górski B, Naumann B, Nondorp D, Chatzigeorgiou M, Kittelmann M, Burkhardt P. Neuropeptide repertoire and 3D anatomy of the ctenophore nervous system. Curr Biol 2021 Dec 6;31(23):5274-5285.e6, doi: 10.1016/j.cub.2021.09.005.
  26. Schneider M, Vollmer L, Potthoff AL, Ravi VM, Evert BO, Rahman MA, Sarowar S, Kueckelhaus J, Will P, Zurhorst D, Joseph K, Maier JP, Neidert N, dÉrrico P, Meyer-Luehmann M, Hofmann UG, Dolf A, Salomini P, Güresir E, Enger PØ, Chekenya M, Pietsch T, Schuss P, Schnell O, Westhoff MA, Beck J, Vatter H, Waha A, Herrlinger U, Heiland DH. Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma. Neuro-Oncol 2021, April 16. doi:10.1093/neuronc/noab092.
  27. Shafiee S, Gelebart P, Popa M, Hellesøy M, Hovland R, Forthun RB, Lee J, Tohyama K, Molven A, Parekkadan B, Gjertsen BT, Kittang AO, McCormack E. Preclinical charcterisation and development of a novel myelodysplastic syndrome-derived cell line. Br J Haematol 2021 Apr, 193(2):415-419. doi:10.1111/bjh.17372.
  28. Velasco K, St-Louis JL, Hovland HN, Thompson N, Ottesen Å, Choi MH, Pedersen L, Njølstad PR, Arnesen T, Fjeld K, Aukrust I, Myklebust LM, Molven A. Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function in vitro. J Inherit Metab Dis 2021 Jan, 44(1):240-252. doi:10.1002/jimd.12309.
  29. Waløen K, Jung-Kc K, Vecchia ED, Pandey S, Gasparik N, Døskeland A, Patil S, Kleppe R, Hritz J, Norton WHJ, Martinez A, Haavik J. Cysteine modification by ebselen reduces the stability and cellular levels of 14-3-3 proteins. Mol Pharmacol 2021 May 24. doi:10.1124/molpharm.120.000184.
  30. Aasen SN, Espedal H, Keunen O, Adamsen TCH, Bjerkvig R, Thorsen F. Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis. Neurooncol Adv 2021 Oct 14;3(1):vdab151, doi: 10.1093/noajnl/vdab151.
2020
  1. Balafkan N, Mostafavi M, Siller R, Liang KX, Sullivan G, Bindoff LA. A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates. Sci Rep 2020 Oct 28, 10(1):18498. Doi:10.1038/s41598-020-73656-2.
  2. Beigl TB, Hellesvik M, Saraste J, Arnesen T, Aksnes H. N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus. Exp Cell res 2020 May 15, 390(2):111961. doi:10.1016/j.yexcr.2020.111961.
  3. Engelsen AST, Wnuk-Lipinska K, Bougnad S, Vatter FAP, Tiron C, Villadsen R, Miyano M, Lotsberg ML, Madeleine N, Panahandeh P, Dhakal S, Tan TZ, Peters SD, Grøndal S, Aziz SM, Nord S, Herfindal L, Stampfer MR, Sørlie T, Brekken RA, Straume O, Halberg N, Gausdal G, Thiery JP, Akslen LA, Petersen OW, LaBarge M, Lorens JB. AXL is a driver of stemness in normal mammary gland and breast cancer. iScience 2020 Oct 7, 23(11):101649. doi:10.1016/j.isci.2020.101649.
  4. Fonnes T, Strand E, Fasmer KE, Berg HF, Espedal H, Sortland K, Stefansson I, Bjørge L, Haldorsen IS, Krakstad C, McCormack E. Near-infrared fluorescent imaging for monitoring of treatment response in endometrial carcinoma patient-derived xenograft models. Cancers (Basel) 2020 Feb 6, 12(2):370. doi:10.3390/cancers12020370.
  5. Ghila L, Bjørlykke Y, Legøy TA, Vethe H, Furuyama K, Chera S, Ræder H. Bioinformatics analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4a mutation. Biomedicines 2020 Jun 27, 8(7):179. doi:10.3990/biomedicines8070179.
  6. Herdlevær I, Kråkenes T, Schubert N, Vedeler CA. Localization of CDR2L and CDR2 in paraneoplastic cerebellar degeneration. Ann Clin Transl Neurol 2020 Nov, 7(11):2232-2242. doi:10.1002/acn3.51212.
  7. Hong Y, Liang X, Gilhus NE. AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study. Sci Rep 2020 Jul 8, 10(1):11230. doi:10.1038/s41598-020-68185-x.
  8. Islam T, Larsen Ø, Birkeland NK. A novel cold-adapted Methylovulum species, with a high C16:1w5c content, isolated from an arctic thermal spring in Spitsbergen. Microbes Environ 2020, 35(3):ME20044. Doi:10.1264/jsme2.ME20044.
  9. Jain S, Yassin MA, Fuoco T, Liu H, Mohamed-Ahmed S, Mustafa K, Finne-Wistrand A. Engineering 3D degradable, pliable scaffolds toward adipose tissue regeneration; optimized printability, simulations and surface modification. J Tissue Eng 2020 Sep 16, 11:2041731420954316. doi:10.1177/2041731420954316.
  10. Kleinmanns K, Bischof K, Anandan S, Popa M, Akslen LA, Fosse V, Gjertsen BT, Bjørge L, McCormack E. CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma. EBioMedicine 2020 Jun, 56:102782. doi:j.ebiom.2020.102782.
  11. Kleinmanns K, Fosse V, Davidson B, de Jalón EG, Tenstad O, Bjørge L, McCormack E. CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model. EBioMedicine 2020 Jun, 56:102783. doi:10.1016/j.ebiom.2020.102783.
  12. Legøy T, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S. In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiol (Oxf) 2020 Apr, 228(4):e13433. doi:10.1111/apha.13433.
  13. Legøy TA, Mathisen AF, Salim Z, Vethe H, Bjørlykke Y, Abadpour S, Paulo Z, Scholz H, Ræder H, Ghila L, Chera S. In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. Front Cell Dev Biol 2020 Feb 25, 8:109. doi:10.3389/fcell.2020.00109.
  14. Legøy TA, Vethe H, Abadpour S, Strand BL, Scholz H, Paulo JA, Ræder H, Ghila L, Chera S. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. Sci Rep 2020 Jan 15, 10(1):414. doi:10.1038/s41598-019-57305-x.
  15. Liang KX, Kristiansen CK, Mostafavi S, Vatne GH, Zantingh GA, Kianian A, Tzoulis C, Høyland LE, Ziegler M, Perez RM, Furriol J, Zhang Z, Balafkan N, Hong Y, Siller R, Sullivan GJ, Bindoff LA. Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations. EMBO Mol Med 2020 Oct 7, 12(10):e12146. doi:10.15252/emmm.202012146.
  16. Lotsberg ML, Wnuk-Lipinska K, Terry S, Tan TZ, Lu N, Trachsel-Moncho L, Røsland GV, Siraji MI, Hellesøy M, Rayford A, Jacobsen K, Ditzel HJ, Vintermyr KO, Bivona TG, Minna J, Brekken RA, Baguley B, Micklem D, Akslen LA, Gausdal G, Simonsen A, Thiery JP, Chouaib S, Lorens JB, Engelsen AST. AXL targeting abrogates autophagic flux and induces immunogenic cell death in drug-resistant cancer cells. J Thorac Oncol 2020 Jun, 15(6):973-999. doi:10.1016/j.tho.2020.01.015.
  17. Mahootchi E, Homaei SC, Kleppe R, Winge I, Hegvik TA, Megias-Perez R, Totland C, Mogavero F, Baumann A, Glennon JC, Miletic H, Kursula P, Haavik J. GADL1 is a multifunctional decarboxylase with tissue-specific roles in -alanine and carnosine production. Sci Adv. 2020 Jul 17;6(29):eabb3713. doi: 10.1126/sciadv.abb3713)
  18. Omsland M, Andresen V, Gullaksen SE, Ayuda-Durán P, Popa M, Hovland R, Brendehaug A, Enserink J, McCormack E, Gjertsen BT. Tyrosine kinase inhibitors and interferon-a increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines. FASEB J 2020 Mar, 34(3):3773-3791. doi:10.1096/fj.201802061RR.
  19. Pedersen L, Panahandeh P, Siraj M, Knappskog S, Lønning PE, Gordillo R, Scherer PE, Molven A, Teigen K, Halberg N. Golgi-localized PAQR4 mediates antiapoptotic ceramidase activity in breast cancer. Cancer Res 2020 Jun 1, 80(11):2163-2174. doi:10.1158/0008-5472.CAN-19-3177.
  20. Shanbhag S, Suliman S, Bolstad AI, Stavropoulos A, Mustafa K. Xeno-free spheroids of human gingiva-derived progenitor cells for bone tissue engineering. 2020 Aug 19, 8:968. doi:10.3389/fbioe.2020.00968.
  21. Varhaug KN, Kråkenes T, Alme MN, Vedeler CA, Bindoff LA. Mitochondrial complex IV is lost in neurons in the cuprizone mouse model. Mitochondrion 2020 Jan, 50:58-62. doi:10.1016/j.mito.2019.09.003.
  22. Xing Z, Cai J, Sun Y, Cao M, Li Y, Xue Y, Finne-Wistrand A, Mustafa K. Altered hydrophilicity on copolymer scaffolds stimulate the osteogenic differentiation of human mesenchymal stem cells. Polymers (Basel) 2020 Jun 29, 12(7):1453. doi:10.3390/polym12071453.
  23. Yamada S, Yassin MA, Weigel T, Schmitz T, Hansmann J, Mustafa K. Surface activation with oxygen plasma promotes osteogenesis with enhanced extracellular matrix formation in three-dimensional microporous scaffolds. J Biomed Mater Res A, 2021 Mar 5. doi:10.1002/jbm.a.37151.
  24. Zhang X, Ding K, Ji J, Parajuli H, Aasen SN, Espedal H, Huang B, Chen B, Wang J, Li X, Thorsen F. Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosomal membrane permeabilization. Am J Cancer Res 2020, 10(2):545-563.
  25. Åsrud KS, Bjørnstad R, Kopperud R, Pedersen L, van der Hoeven B, Karlsen TV, Rygh CB, Curry FR, Bakke M, Reed RK, Tenstad O, Døskeland SO. Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions. Acta Physiol (Oxf) 2020 May, 229(1):e13442. doi:10.1111/apha.13442.
2019
  1. Aasen SN, Espedal H, Holte CF, Keunen O, Karlsen TV, Tenstad O, Maherally Z, Miletic H, Hoang T, Eikeland AV, Baghirov H, Olberg DE, Pilkington GJ, Sarkar G, Jenkins RB, Sundstrøm T, Bjerkvig R, Thorsen F. Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier. Mol Cancer Ther. 2019 Nov;18(11):2171-2181. doi: 10.1158/1535-7163.MCT-19-0160. Epub 2019 Aug 29.
  2. Aasen SN, Parajuli H, Hoang T, Feng Z, Stokke K, Wang J, Roy K, Bjerkvig R, Knappskog S, Thorsen F. Effective treatment of metastatic melanoma by combining MAPK and PI3K signaling pathway inhibitors. Int J Mol Sci. 2019 Aug 29;20(17). pii: E4235. doi: 10.3390/ijms20174235.
  3. Bernatz S, Ilina EI, Devraj K, Harter PN, Mueller K, Kleber S, Braun Y, Penski C, Renner C, Halder R, Jennewein L, Solbach C, Thorsen F, Pestalozzi BC, Mischo A, Mittelbronn M. Impact of docetaxel on blood-brain barrier function and formation of breast cancer brain metastases. J Exp Clin Cancer Res. 2019 Oct 29;38(1):434. doi: 10.1186/s13046-019-1427-1
  4. Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. Int J Obes (London) 2019 Nov, 43(11):2151-2162.
  5. Bockwoldt M, Houry D, Niere M, Gossmann TI, Reinartz I, Schug A, Ziegler M, Heiland I. Identification of evolutionary and kinetic drivers of NAD-dependent signaling. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15957-15966. doi: 10.1073/pnas.1902346116. Epub 2019 Jul 24. PMID: 31341085
  6. Curry FE, Taxt T, Rygh CB, Pavlin T, Bjørnstad R, Døskeland SO, Reed RK. Epac-/- mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast-enhanced magnetic resonance imaging with contrast‐enhanced magnetic resonance imaging with contrast agents of different molecular weights. Acta Physiol (Oxf). 2019 Mar;225(3):e13199. doi: 10.1111/apha.13199. Epub 2018 Nov 2.PMID:    30300965  
  7. Espedal H, Fonnes t, Fasmer KE, Krakstad C, Haldorsen IC. Imaging of preclinical endometrial models for monitoring tumor progression and response to therapy. Cancers (Basel) 2019 Nov 27;11(12). doi: 10.3390/cancers11121885.
  8. Forthun RB, Hellesøy M, Sulen A, Kopperud RK, Sjøholt G, Bruserud Ø, McCormack E, Gjertsen BT. Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia. J Cancer Res Clin Oncol. 2019 Jul;145(7):1729-1749. doi: 10.1007/s00432-019-02931-1. Epub 2019 May 20.
  9. Fuoco T, Ahlinder A, Jain S, Mustafa K, Finne-Wistrand A. Poly(e-caprolactine-co-p-dioxane): A degradable and printable copolymer for plianle 3D scaffolds fabrication toward dipose tissue regeneration. Biomacromolecules 2019 Oct 4. doi: 10.1021/acs.biomac.9b01126.
  10. Gras Navarro A, Espedal H, Joseph JV, Trachsel-Moncho L, Bahadour M, Gjertsen BT, Kristoffersen EK, Simonsen A, Miletic H, Enger PØ, Rahman MA, Chekenya M. Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 apoptosis and prolongs animal survival. Cancers 2019 Jul 17;11(7). Doi: 10.3390/cancers11070996.
  11. Haugse R, Langer A, Gullaksen SE, Sundøy SM, Gjertsen BT, Kotopoulis S, McCormack E. Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells.Pharmaceutics. 2019 Jul 6;11(7). pii: E319. doi: 10.3390/pharmaceutics11070319.
  12. Humisto A, Jokela J, Teigen K, Wahlsten M, Permi P, Sivonen K, Herfindal L. Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes. Biochim Biophys Acta Biomembr 2019 Aug 1, 1861(89): 1510-1521.
  13. Kråkenes T, Herdlevaer I, Raspotnig M, Haugen M, Schubert M, Vedeler CA. CDR2L Is the Major Yo Antibody Target in Paraneoplastic Cerebellar Degeneration. Ann Neurol. 2019 Aug;86(2):316-321. doi: 10.1002/ana.25511. Epub 2019 Jun 13. PMID: 31148214
  14. Kumpala EP, Lopez AJ, Tajedin L, Han H, Kursula I. Atomic view into plasmodium actin polymerization, ATP hydrolysis, and fragmentation. PLoS Biol 2019 Jun 14;17(6):e300315. doi: 10.1371/journal.pbio.3000315.
  15. Munir A, Døskeland A, Avery SJ, Fuoco T, Mohamed-Ahmed S, Lygre H, Finne-Wistrand A, Sloan AJ, Waddington RJ, Mustafa K, Suliman S. Efficacy of copolymer scaffolds delivering human demineralized dentine matrix for bone regeneration. J Tissue Eng 2019 May 31;10:2041731419852703.
  16. Osuagwu N, Dölle C, Tzoulis C. Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix. PLoS One. 2019 Jul 19;14(7):e0219909. doi: 10.1371/journal.pone.0219909. eCollection 2019. PMID: 31323073
  17. Rahman MA, Gras Navarro A, Brekke J, Engelsen A, Bindesbøll C, Sarowar S, Bahadour M, Bifulco E, Goplen D, Waha A, Lie SA, Gjertsen BT, Selheim F, Enger PØ, Simonsen A, Chekenya M. Bortezomid administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. Br J Cancer 2019 Oct;121(7):545-555.
  18. Rashad A, Suliman S, Mustafa K, Pedersen TØ, Campodoni E, Sandri M, Syverud K, Mustafa K. Inflammatory responses and tissue reactions to wood-based nanocellulose scaffolds. Mater Sci Eng C Mater Biol Appl 2019, April, 97:208-221.
  19. Røsland GV, Dyrstad SE, Tusubira D, Helwa R, Tan TZ, Lotsberg ML, Pettersen IKN, Berg A, Kindt C, Hoel F, Jacobsen K, Arason AJ, Engelsen AST, Ditzel HJ, Lønning PE, Krakstad C, Thiery JP, Lorens JB, Knappskog S, Tronstad KJ. Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC. Cancer Metabol 2019 June 1, 7:6. doi: 10.1186/s40170-019-0197-8.
  20. Smeland HY, Lu N, Karlsen TV, Salvesen G, Reed RK, Stuhr L. Stromal integrin a11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors. BCM Cancer 2019 March, 19(1):234. doi: 10.1186/s12885-019-5449-z.
  21. Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun. 2019 Apr 10;7(1):55. doi: 10.1186/s40478-019-0712-8.
  22. Terry S, Abdou A, Engelsen AST, Buart S, Dessen P, Corgnac S, Collares D, Meurice G, Gausdal G, Baud V, Saintigny P, Lorens JB, Thiery JP, Mami-Chouaib F, Chouaib S. AXL targeting overcomes human lung cancer cell resistance to NK- and CTL-mediated cytotoxicity. Cancer Immunol Res 2019 Nov, 7(11): 1789-1802.
  23. Veruki ML, Zhou Y, Castilho Á, Morgans CW, Hartveit E. Extrasynaptic NMDA Receptors on Rod Pathway Amacrine Cells: Molecular Composition, Activation, and Signaling. J Neurosci. 2019 Jan 23;39(4):627-650. doi: 10.1523/JNEUROSCI.2267-18.2018. Epub 2018 Nov 20. PMID: 30459218
  24. Yassin MA, Fuoco T, Mohamed-Ahmed H. Mustafa K, Finne-Wistrand a. 3D and poprous RGDC-functionalized polyester-based scaffolds as a niche to induce osteogenic differentiation of human bone marrow stem cells. Macromol Biosci 2019 June, 19(6):e1900049.
  25. Zhang Z, Gao Z, Rajthala S, Sapkota D, Dongre H, Parajuli H, Suliman S, Das R, Li L, Bindoff LA, Costea DE, Liang X. Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts. Cell Mol Life Sci. 2019 Jul 3. doi: 10.1007/s00018-019-03209-y. [Epub ahead of print]
  26. Zhang Z, Liang X, Fan Y, Gao Z, Bindoff LA, Costea DE, Li L. Fibroblasts rescue oral squamous cancer cell from metformin-induced apoptosis via alleviating metabolic disbalance and inhibiting AMPK pathway. Cell Cycle. 2019 May;18(9):949-962. doi: 10.1080/15384101.2019.1598727. Epub 2019 Apr 23.
  27. Jung-Kc K, Himmelreich N, Prestegård KS, Shi TS, Scherer T, Ying M, Jorge-Finnigan A, Thöny B, Blau N, Martinez A. Phenylalanine hydroxylase variants interact with the co-chaperone DNAJC12. Hum Mutat. 2019 Apr;40(4):483-494. doi: 10.1002/humu.23712. Epub 2019 Feb 6. PMID: 30667134
2018
  1. Bezem MT, Johannessen FG, Jung-KC K, Gundersen ET, Jorge-Finigan A, Ying M, Betbeder D, Herfindal L, Martinez A. Stabiliztion of human tyrosine hydroxylase in maltodextrin nanoparticles for delivery to neuronal cells and tissue. Bioconjugate Chem 2018;29:493-502.
  2. Bjørndal B, Alterås EK, Lindquist C, Svardal A, Skorve J, Berge RK. Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice. Nutr Metab (London) 2018 Jan 29;15:10. doi:10.1186/s12986-018-0241-7.
  3. Bozickovic O, Skartveit L, Engelsen AST, Helland T, Jonsdottir K, Flågeng MH, Fenne IS, Janssen E, Lorens JB, Bjørkhaug L, Sagen JV, Mellgren G. A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. 
  4. Dabija-Wolter G, Al-Zubaydi SS, Mohammed MMA, Bakken V, Bolstad AI. The effect of metronidazole plus amoxillin or metronidazole plus penicillin V on periodontal pathogens in an in vitro biofilm model. Clin Exp Dent Res 2018 Jan 2;4(1):6-12.
  5. Drazic A, Aksnes H, Marie M, Boczkowska M, Varland S, Timmerman E, Foyn H, Glomnes N, Rebowski G, Impens F, Geveart K, Dominguez R, Arnesen T. NAA80 is actin´s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. Proc Natl Acad Sci U S A Apr 24;115(7):4399-4404.
  6. Hartveit E, Zandt BJ, Madsen E, Castilho A, Mørkve SH, Veruki ML. AMPA receptors at ribbon synapses in the mammalian retina: Kinetic models and molecular identity. Brain Struct Funct 2018 Mar;223(2):769-804.
  7. Ibrahim M, Schoelermann J, Mustafa K, Chera MR. RiO2 nanoparticles disrupt cell adhesion and the architecture of cytoskeletal networks of human osteoblast-like cells in a size dependent manner. J Biomed Mater Res A 2018 Oct, 106(20):2582-2593. doi:10.1002/jbm.a.36448.
  8. Ibrahim M, Schoelermann J, Mustafa K, Cimpan MR. TiO2 nanoparticles disrupt cell adhesion and the architecture of cytoskeletal networks of human osteoblast-like cells in a size dependent manner. J Biomed Mater Res A 2018 Apr 30;doi 10.1002/jbm.a.36448.
  9. Ibrahim M, Xue Y, Ostermann M, Sauter A, Steinmueller-Nethl D, Schweeberg S, Krueger A, Cimpan MR, Mustafa K. In vitro cytotoxicity assessment of nanodiamond particles and their osteogenic potential. J Biomed Mater Res A 2018 Jun;106(6):1697-1707.
  10. Johannessen TC, Hasan-Olive MM, Zhu H, Denisova O, Grudic A, Latif MA, Saed H, Varughese JK, Røsland GV, Yang N, Sundstrøm T, Nordal A, Tronstad KJ, Wang J, Lund-Johansen M, Simonsen A, Janji B, Westermarck J, Bjerkvig R, Prestegarden L. Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. Int J Cancer. 2019 Apr 1;144(7):1735-1745. doi: 10.1002/ijc.31912. Epub 2018 Dec 11.
  11. Obad N, Espedal H, Jirik R, Sakariassen PØ, Rygh CB, Lund-Johansen M, Taxt T, Niclou SP, Bjerkvig R, Keunen O. Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma. J Cereb Blood Flow Metab 2018 Oct, 38(10):1741-1753. doi:10.1177/0271678X17714656.
  12. Olsen LC, Kourtesis I, Busengdal H, Jensen MF, Hausen H, Chourrout D. Evidence for a centrosome-attracting body like structure in germ-soma segregation during early development, in the urochordate Oikopleura dioica. BMC Dev Biol 2018 Feb 27, 18(1):4. doi:10.1186/s12861-018-0165-5.
  13. Omsland M, Pise-Masison C, Fujikawa D, Galli V, Fenizia C, Parks RW, Gjertsen BT, Franchini G, Andresen V. Inhibition of tunneling nanotube (TNT) formation and human T-cell leukemia virus Type 1 (THLV-1) transmission by cytarabine. Sci Rep 2018 Jul 24, 8(1):11118. doi:10.1038/s41598-018-29391-w.
  14. Panja D, Vedeler CA, Schubert M. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol 2018 Apr 21;doi:10.1111/nan.12492.
  15. Rashad A, Mohamed-Ahmed S, Ojansivu M, Berstad K, Yassin MA, Kivijärvi T, Heggset EB, Syverud K, Mustafa K. Coating 3D printed polycaprolactone scaffolds with nanocellulose promotes growth and differentiation of mesenchymal stem cells. Biomacromolecules 2018, 19, 4307-4319.
  16. Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Bendiksen B, Robinson EL, Aronsen JM, Herum KM, Danielsen HE, Sjaastad I, Christensen D, Gullberg D. Overexpression of integrin a11 induces cardiac fibrosis in mice. Acta Physiol (Oxf) 2018 Feb;222(2). Doi.10.1111/apha.12932.
  17. Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Chrostensen G, Gullberg D. Overexpression of integrin a11 induces cardiac fibrosis in mice. Acta Physiol (Oxf) 2018 Feb, 222(2). doi:10.1111/apha.12932. 
  18. Saraste J, Marie M. Intermediate compartment (IC): from pre-Golgi vacuoles to a semi-autonomous membrane system. Histochem Cell Biol 2018 Nov, 150(5):407-430. doi:10.1007/s00418-018-1717-2.
  19. Sharma S, Sapkota D, Xue Y, Rajthala S, Yassin MA, Finne-Wistrand A, Mustafa K. Delivery of VEGFA in bone marrow stromal cells seeded in a copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model. Stem Cell Res Ther 2018 Jan 31, 9(1):23. doi:10.1186/s13287-108-0778-4.
  20. Sønstevold T, Johannessen AC, Reed RK, Salvesen GS, Stuhr L. Hyperbaric oxygen treatment did not significantly affect radiation injury in the mandibular area of rats. Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Feb;125(2):112-119.
  21. Taxt T, Reed RK, Pavlin T, Brekke Rygh C, Andersen E, Jirik R. Semi-parametric arterial input functions for quantitative dynamic contrast enhanced magnetic resonance imaging in mice. Magn Reson Imaging 2018 Feb;46:10-20.
  22. Totland C, Kråkenes T, Mazienga K, Haugen M, Vedeler C. Expression of the onconeural protein CDR1 in cerebellum and ovarian cancer. Oncotarget 2018 May 8;9(35):23975-23986.
  23. Vatter FAP, Schapiro D, Chang H, Borowsky AD, Lee JK, Parvin B, Stampfer MR, LaBarge M, Bodenmiller B, Lorens JB. High-dimensional phenotyping identifies age-emergent cells in human mammary epithelia. Cell Rep 2018 Apr 24, 23(4):1205-1219. doi:10.1016/j.celrep.2018.03.114.
2017
  1. Aass T, Stangeland L, Chambers DJ, Hallström S, Rossmann C, Podesser BK, Urban M, Nesheim K, Haaverstad R, Matre K, Grong K. Myocardial energy metabolism and ultrastructure with depolarizing cardioplegia in a porcine model. Eur J Cardiothorac Surg 2017 Jul 1;52(1):180-188.
  2. Aukrust I, Rosenberg LA, Ankerud MM, Bertelsen V, Hollås H, Saraste J, Grindheim AK, Vedeler A. Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes. FEBS Open Bio 2017 Jan 17;7(2):160-73.
  3. Bahadour M, Gras Navarro A, Rahman MA, Dominguez-Valentin M, Sarowar S, Ulvestad E, Njølstad P, Lie SA, Kristoffersen EK, Bratland E, Chekenya M. Increased infiltration and tolerized antigen-specific CD8+ Tem cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients. Oncoimmunology 2017 Jun 5;6(8):e1336272.
  4. Binder V, Bergum B, Jaisson S, Gillery P, Scavenius C, Spriet E, Nyhaug AK, Roberts HM, Chapple ILC, Hellvard A, Delaleu N, Mydel P. Impact of fibrinogen carbamylation on fibrin clot formation and stability. Thromb Haemost 2017 May 3;117(5):899-910. 
  5. Bittins M, Wang X. TNT-induced phagocytosis: Tunneling nanotubes mediate the transfer of pro-phagocytic signals from apoptotic to viable cells. J Cell Physiol 2017 Sep;232(9):2271-2279.
  6. Brattekås B, Steinsbø M, Graue A, Fernø MA, Espedal H, Seright RS. New Insight Into Wormhole Formation in Polymer Gel During Water Chase Floods With Positron Emission Tomography. SPE journal. , 2017, Vol.22(1), p.032-040
  7. Johansson BB, Fjeld K, Solheim MH, Shirakawa J, Zhang E, Keindl M, Hu J, Lindqvist A, Døskeland A, Mellgren G, Flatmark T, Njølstad PR, Kulkarni RN, Wierup N, Aukrust I, Bjørkhaug L. Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. Mol Cell Endocrinol 2017 Oct 15;454:146-157.
  8. Jorge-Finnigan A, Kleppe R, Jung-KC K, Ying M, Marie M, Rios-Madrigan I, Salvatore MF, Saraste J, Martinez A. Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. J Biol Chem 2017 Aug 25;292(34):14092-14107.
  9. Karjalainen R, Pemovska T, Popa M, Liu M, Javarappa KK, Majumder MM, Yadav B, Tamborero D, Tang J, Bychkov D, Kontro M, Parsons A, Suvela M, Mayoral Safont M, Porkka K, Aittokallio T, Kallioniemi O, McCormack E, Gjertsen BT, Wennerberg K, Knowles J, Heckman CA. JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal-induced protection of AML. Blood 2017 Aug 10;130(6):789-802.
  10. Kopperud RK, Rygh CB, Karlsen TV, Krakstad C, Kleppe R, Høyvik EA, Bakke M, Tenstad O, Selheim F, Lid`en Å, Masden L, Pavlin T, Taxt T, Kristiansen K, Curry FE, Reed RK, Døskeland SO. Increased vascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiol (Oxf) 2017 Feb;219(2):441-452.
  11. Kotopoulis S, Stigen E, Popa M, Safont MM, Healey A, Kvåle S, Sontum P, Gjertsen BT, Gilja OH, McCormack E. Sonoporation with acoustic cluster therapy (ACT) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma. J Control Release 2017 Jan 10;245:70-80.
  12. Leandro J, Saraste J, Leandro P, Flatmark T. PKU mutation p.G46S prevents the stereospecific binding of I-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain. FEBS Open Bio 2017 Jan 21;7(2):195-203.
  13. Leiss L, Mutlu E, Øyan A, Yan T, Tsinkalovsky O, Sleire L, Petersen K, Rahman MA, Johannesen M, Mitra SS, Jacobsen HK, Talasila KM, Miletic H, Jonassen I, Li X, Brons NH, Kalland KH, Wang J, Enger PØ. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer 2017 Feb 7;17(1):108. Doi:1186/s12885-017-3109-8.
  14. Lindquist C, Bjørndal B, Rossmann CR, Tusubira D, Svardal A, Røsland GV, Tronstad KJ, Hallström S, Berge RK. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. J Lipid Res 2017 Jul;58(7):1362-1373.
  15. Myrum C, Soulé J, Bittins M, Cavagnini K, Goff K, Ziemek SK, Eriksen MS, Patil S, Szum A, Nair RR, Bramham CR. Arc interacts with the integral endoplasmatic reticulum protein, calnexin. Front Cell Neurosci 2017 Sep 20;11:294, doi:10.3389/fncel.2017.00294.
  16. Niklasson M, Maddalo G, Sramkova Z, Mutlu E, Wee S, Sekyrova P, Schmidt L, Fritz N, dehnisch I, Kyriatzis G, Krafcikova M, Carson BB, Feenstra J, Marinescu VD, Segerman A, Haraldsson M, Gustavsson AL, Hammarström LG, Jenmalm-Jensen A, Uhrbom L, Altelaar AF, Linnarsson S, Uhlén P, Trantirek L, Vincent CT, Nelander S, Enger PØ, Andäng M. Membran-depolarizing channel blockers induce selective glioma cell death by impairing nutrient transport and unfolded protein/amino acid responses. Cancer Res 2017 Jan 13. Pii: canres.2274.2016. doi: 10.1158/0008-5472CAN-16-2274.
  17. Nygaard G, Herfindal L, Asrud K, Bjørnstad R, Kopperud RK, Oveland E, Berven FS, Myhren L, Hoivik EA, Lunde THF, Bakke M, Døskeland SO, Selheim F. Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbb expression. Sci Rep 2017 Aug 18;7:8725, doi:10.1038/s41598-017-08975-y.
  18. Omsland M, Bruserud Ø, Gjertsen BT, Andresen V. Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-kB inhibition in acute myeloid leukemia (AML). Oncotarget 2017 Jan 31;8(5):7946-7963.
  19. Tveitarås MK, Reigstad I, Leiss L, Reed RK, Stuhr L. Single factors alone can induce mesenchymal-like morphology, but not promote full EMT in breast cancer cell lines with different hormone statuses. Exp Cell Res 2017 Oct;359(1):257-265.
  20. Vethe H, Bjørlykke Y, Ghila LM, Paulo JA, Scholz H, Gygi SP, Chera S, Ræder H. Probing the missing mature b-cell proteomic landscape in differentiating patient iPSC-derived cells. Sci Rep 2017 Jul 6;7(1):4780. Doi:10.1038/s41598-017-04979-w.
  21. Yassin MA, Mustafa K, Xing Z, Sun Y, Fasmer KE, Waag T, Krueger A, Steinmüller-Nethl D, Finne-Wistrand A, Leknes KN. A copolymer scaffold functionalized with nanodiamond particles enhances osteogenic metabolic activity and bone regeneration. Macromol Biosci 2017 Jan 24. Doi: 10.1002/mabi.201600427.
  22. Zhang X, Xu R, Zhang C, Xu Yangyang, Han M, Huang B, Chen A, Qiu C, Thorsen F, Prestegarden L, Bjerkvig R, Wang J, Li X. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. J Exp Clin Cancer Res 2017;36:118.
  23. Zhu H, Leiss L, Yang N, Rygh CB, Mitra SS, Cheshier SH, Weissman IL, Huang B, Miletic H, Bjerkvig R, Enger PØ, Li X, Wang J.  Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy. Oncotarget 2017 Jan 6. Doi 18632/oncotarget.14553.
2016
  1. Arnesen V, Erikstein BS, Mukherjee H, Sulen A, Popa M, Sørnes S, Reikvam H, Chan KP, Hovland R, McCormack E, Bruserud Ø, Myers AG, Gjertsen BT. Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia. Cell Death Dis 2016 Dec 1;7(12):e2497. Doi: 10.1038(cddis.2016.392.
  2. Baumann A, Jorge-Finnigan A, Jung-Kc K, Sauter A, Horvath I, Morozova-Roche LA, Martinez A. Tyrosine hydroxylase binding to phospholipid membranes prompts its amyloid aggregation and compromises bilayer integrity. Sci Rep Dec 22;6:39488. Doi: 10.1038/srep39488.
  3. Bittins M, Wang X. TNT-induced phagocytosis: Tunneling nanotubes mediate the transfer of pro-phagocytic signals from apoptotic to viable cells. J Cell Physiol 2016 Sep 3. Doi: 10.102/jcp.25584.
  4. Bougnaud S, Golebiewska A, Oudin A, Keunen O, Harter PN, Mäder L, Azuaje F, Fritah S, Stieber D, Kaoma T, Vallar L, Brons NHC, Daubon T, Miletic H, Sundstrøm T, herold-Mende C, Mittelbronn M, Bjerkvig R, Niclou S. Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma. Oncotarget May 31;7(22):31955-71.
  5. Dominguez-Valentin M, Gras Navarro A, Rahman AM, Kumar S, Reti`ere C, Ulvestad E, Kristensen V, Lund-Johansen M, Lie BA, Enger PØ, Njølstad G, Kristoffersen E, Lie SA, Chekenya M. Identification of a natural killer cell receptor allele that prolongs survival of cytomegalovirus-positive glioblastoma patients. Cancer Res 2016 Sep 15;76(18):5326-36.
  6. Eskilsson E, Røsland GV, Talasila KM, Knappskog S, Keunen O, Sottoriva A, Foerster S, Solecki G, Taxt TJirik R, Fritah S, Harter P, Välk K, Al Hossain J, Joseph JV, Jahedi R, Saed HS, Piccirillo SG, Spiteri I, Leiss L, Euskirchen P, Graziani G, Daubon T, Lund-Johansen M, Enger PØ, Winkler F, Ritter CA, Niclou S, Watts C, Bjerkvig R, Miletic R. EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation. Neuro Oncol 2016;18(12):1644-1655.
  7. Grindheim AK, Hollås H, Raddum AM, Saraste J, Vedeler A. reactive oxygen species exert opposite effects on Tyr23 phophorylation of the nuclear and cortical pools of annexin A2. J Cell Sci 2016 Jan;129(2):314-28.
  8. Helland Ø, Popa M, Bischof K, Gjertsen BT, McCormack E, Bjørge L. The HDACi Panobinostat shows growth inhibition in vitro and in a bioluminescent orthotopic surgical xenograft model of ovarian cancer. PLoS One 2016 Jun 28;11(6):e0158208.
  9. Kuipers SD, Trentani A, Tiron A, Mao X, Kuhl D, Bramham CR. BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. Sci Rep 2016 Feb 18;6:21222.
  10. Leitch C, Osdal T, Andresen V, Molland M, Kristiansen S, Nguyen XN, Bruserud Ø, Gjertsen BT, McCormack E. Hydroxyurea synergizes with valrpoic acid in wild-type p53 acute myeloid leukemia. Ocotarget 2016 feb 16;7(7):8105-18.
  11. Mamaeva V, Niemi R, Beck M, Özliseli E, Desai D, Landor S, Gronroos T, Kronqvist P, Pettersen IK, McCormack E, Rosenholm JM, Linden M, Sahlgren C. Inhibiting Notch activity in breast cancer stem cells by glucose functionalised nanoparticles carrying g-secretase inhibitors. Mol Ther 2016 Dec 26. doi: 10.1038/mt.2016.42.
  12. Netland IA, Førde HE, Sleire L, Leiss L, Rahman MA, Skeie BS, Gjerde CH, Enger PØ, Goplen D. Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models. BMC Cancer 2016 Aug 19;16:657. Doi: 10.1186/s12885-016-2712-4.
  13. Netland IA, Førde HE, Sleire L, Leiss L, Rahman MA, Skeie BS, Miletic H, Enger PØ, Goplen D. Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats. J Neurooncol 2016 Aug;129(1):57-66.
  14. Qu Y, Gharbi N, Yuan X, Olsen JR, Blicher P, Dalhus B, Brokstad KA, Lin B, Øyan AM, Zhang W, Kalland KH, Ke X. Axitinib blocks Wnt/b-catenin signaling and directs asymmetric cell division in cancer. Proc Natl Acad Sci U S A 2016 Aug 16;113(33):9339-44.
  15. Reigstad I, Smeland HY, Skogstrand T, Sortland K, Schmid MC, Reed RK, Stuhr L. Stromal inytegrin a11b1 affects RM11 prostate and 4T1 breast xenograft tumors differently. PLoS One 2016 Mar 18;11(3):e0151663.
  16. Reigstad I, Sortland RK, Skogstrand T, Reed RK, Stuhr L. The effect of stromal integrin b3-deficiency on two different tumors in mice. Cancers 2016 Jan 12;8(1). doi: 10.3390/cancers8010014.
  17. Sand K, Theorell J, Bruserud Ø, Bryceson YT, Kittang AO. Reduced potency of cytotoxic T lymphocytes from patients with high-risk myelodysplastic syndromes. Cancer Immunol Immunother 2016 Sep;65(9):1135-47.
  18. Schoelermann J, Burtey A, Allouni ZE, Gerdes HH, Cimpan MR. Contact-dependent transfer of TIO2 nanoparticles between mammalian cells. Nanotoxicology 2016 Mar;10(2):204-15.
  19. Suliman S, Mustafa K, Krueger A, Steinmüller-Nethl D, Finne-Wistrand A, Osdal T, Hamza AO, Sun Y, Parajuli H, Waag T, Nickel J, Johannessen AC, McCormack E, Costea DE. Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes. Biomaterials 2016 Jul;95:11-21.
  20. Talasila KM, Røsland GV, Hagland HR, Eskilsson E, Flønes IH, Fritah S, Azuaje F, Atai N, Harter PN, Mittelbronn M, Andersen M, Joseph JV, Hossain JA, Vallar L, Noorden CJ, Niclou SP, Thorsen F, Tronstad KJ, Tzoulis C, Bjerkvig R, Miletic H. The angiogenic switch leads to a metabolic shift in human glioblastoma. Neuro Oncol 2016 Sep 3. Pii:now175.
  21. Van Damme P, Kalvik TV, Starheim KK, Jonckheere V, Gevaert K, Arnesen T. A role for human n-alpha acetyltransferase 30 (Naa30) in maintaining mitochondrial integrity.  Mol Cell Proteomics 2016 Nov; 15(11):3361-3372.
Last updated: 10.06.2026