Øystein Eikrem
Stilling
Førsteamanuensis, Leder, Nyreforskningsgruppen.
Tilhørighet
- E-post
- oystein.eikrem@uib.no
- Besøksadresse
-
Haukeland Universitetssykehus, Laboratoriebygget, 9. etg.
5009 Bergen - Postadresse
-
Postboks 7804
5020 Bergen
Øystein Eikrem
Stilling
Førsteamanuensis, Leder, Nyreforskningsgruppen.
Tilhørighet
Forskergrupper
Kort info
Øystein Eikrem er leder for Nyreforskningsgruppen ved Klinisk Institutt 1, UiB og overlege ved Nyreseksjonen ved Medisinsk Klinikk, Haukeland Universitetssykehus.
Han jobber i grenseflaten mellom klinisk nyremedisin og molekylær profilering av nyrebiopsier med presisjonsmedisin som klar målsetning.
Han jobber i grenseflaten mellom klinisk nyremedisin og molekylær profilering av nyrebiopsier med presisjonsmedisin som klar målsetning.
Forskning
Nyreforskningsgruppen er et åpent forum for klinisk og translasjonell nyreforskning i Bergen. Nyreforskningsgruppen har tradisjonelt kombinert humane data med mekanistiske dyremodeller for å studere sykdomsmekanismer, med avanserte molekylære analyser av nyrebiopsier og digital patologi. I tillegg gjennomføres både epidemiologiske studier av risikofaktorer og sykdomsutvikling ved kronisk nyresykdom i tillegg til flere pågående kliniske studier.
Publikasjoner
2025
- Tony Jialiang Chen; Eleni Skandalou; Katarina Fritz-Wallace et al. (2025). Serum proteome analysis detects early molecular signatures of disease progression in IgA nephropathy. (ekstern lenke)
- Simen Femanger Pettersen; Eleni Skandalou; Jessica Furriol Palmer et al. (2025). Reconstruction of Single-Cell Spatial Transcriptomes in Archival Kidney Biopsies. (ekstern lenke)
- Ole Petter Nordbø; Øystein Solberg Eikrem; Philip A. Kalra et al. (2025). Longitudinal serum proteomics identifies inflammatory and metabolic pathways in hypertensive nephrosclerosis progression. (ekstern lenke)
- Marius Altern Øvrehus; Knut Asbjørn Rise Langlo; Sabine Leh et al. (2025). Norwegian kidney biopsy biobank (NorKiBB): organization, baseline characteristics, and generalizability of a low-cost national biobank. (ekstern lenke)
- Mariell Lossius Rivedal; Ole Petter Nordbø; Yngvar Lunde Haaskjold et al. (2025). Lifetime progression of IgA nephropathy: a retrospective cohort study with extended long-term follow-up. (ekstern lenke)
2023
- Øystein Solberg Eikrem; Bjørnar Sandnes Lillefosse; Nicolas Delaleu et al. (2023). Network-Based Assessment of Minimal Change Disease Identifies Glomerular Response to IL-7 and IL-12 Pathways Activation as Innovative Treatment Target. (ekstern lenke)
- Ole Petter Nordbø; Lea Zoe Landolt; Øystein Solberg Eikrem et al. (2023). Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy. (ekstern lenke)
- Mariell Lossius Rivedal; Håvard Mikkelsen; Hans Peter Marti et al. (2023). Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy. (ekstern lenke)
- Hassan Osman Alhassan Elsaid; Mariell Lossius Rivedal; Eleni Skandalou et al. (2023). Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla <sup> −/−</sup> zebrafish model of Fabry disease. (ekstern lenke)
- Nicolas Delaleu; Hans Peter Marti; Philipp Strauss et al. (2023). Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing. (ekstern lenke)
- Miroslav Sekulic; Ibrahim Batal; Satoru Kudose et al. (2023). Kidney Dysfunction and Pathology in the Setting of Hemophagocytic Lymphohistiocytosis. (ekstern lenke)
- Fabian Braun; Ahmed Abed; Dominik Sellung et al. (2023). Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy. (ekstern lenke)
- Philipp Strauss; Øystein Solberg Eikrem; Hans Peter Marti et al. (2023). From archival tissues to systems biology: Using transcriptomics to investigate the progression of kidney disease. (ekstern lenke)
2019
- Øystein Solberg Eikrem; Hans-Peter Marti (2019). New methods clear the dust off old biopsies. RNA sequencing of FFPE kidney biopsies. (ekstern lenke)
- Even Koch; Kenneth Finne; Øystein Solberg Eikrem et al. (2019). Transcriptome-proteome integration of archival human renal cell carcinoma biopsies enables identification of molecular mechanisms. (ekstern lenke)
- Lea Zoe Landolt; Jessica Furriol; Janka Babickova et al. (2019). AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. (ekstern lenke)
2022
- Håvard Mikkelsen; Bjørn Egil Vikse; Øystein Solberg Eikrem et al. (2022). Glomerular proteomic profiling of kidney biopsies with hypertensive nephropathy reveals a signature of disease progression. (ekstern lenke)
- Hassan Osman Alhassan Elsaid; Håkon Tjeldnes; Mariell Lossius Rivedal et al. (2022). Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca<sup>2+</sup> Signaling Similar to Fabry Disease. (ekstern lenke)
- Philipp Strauss; Mariell Rivedal; Andreas Scherer et al. (2022). A multiomics disease progression signature of low-risk ccRCC. (ekstern lenke)
2016
- Øystein Solberg Eikrem; Philipp Strauss; Christian Beisland et al. (2016). Development and confirmation of potential gene classifiers of human clear cell renal cell carcinoma using next-generation RNA sequencing. (ekstern lenke)
- Lea Zoe Landolt; Hans-Peter Marti; Christian Beisland et al. (2016). RNA extraction for RNA sequencing of archival renal tissues. (ekstern lenke)
- Øystein Solberg Eikrem; Christian Beisland; Karin Margrethe Hjelle et al. (2016). Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development. (ekstern lenke)
- Lea Zoe Landolt; Philipp Strauss; Hans-Peter Marti et al. (2016). Next generation sequencing: A tool for this generation of nephrologists. (ekstern lenke)
2017
- Einar Svarstad; Sabine Maria Leh; Rannveig Skrunes et al. (2017). Bedside stereomicroscopy of Fabry kidney biopsies: An easily available method for diagnosis and assessment of sphingolipid deposits. (ekstern lenke)
- Øystein Solberg Eikrem; Rannveig Skrunes; Camilla Tøndel et al. (2017). Pathomechanisms of renal Fabry disease. (ekstern lenke)
- Lea Zoe Landolt; Øystein Solberg Eikrem; Philipp Strauss et al. (2017). Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis. (ekstern lenke)
2018
- Øystein Solberg Eikrem; Tedd Christian Walther; Arnar Flatberg et al. (2018). Fine needle aspirates of kidneys: A promising tool for RNA sequencing in native and transplanted kidneys. (ekstern lenke)
- Philipp Strauss; Hans-Peter Marti; Christian Beisland et al. (2018). Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma. (ekstern lenke)
- Øystein Solberg Eikrem; Hans-Peter Marti (2018). Klarcellet nyrekarsinom er knyttet til epitelial-til- mesenkymal overgang (EMT) og til fibrose. (ekstern lenke)
2021
- Sigrid Nakken; Øystein Solberg Eikrem; Hans Peter Marti et al. (2021). AGAP2-AS1 as a prognostic biomarker in low-risk clear cell renal cell carcinoma patients with progressing disease. (ekstern lenke)
- Øystein Solberg Eikrem; Spiros Kotopoulis; Mihaela-Lucia Popa et al. (2021). Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys. (ekstern lenke)